Regulation of Calcium and Magnesium
Regulation of Calcium and Magnesium
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DOI：
10.1002/9781118453926.ch22
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
M. Favus;D. Goltzman
中科院分区：
文献类型：
--
作者：
M. Favus;D. Goltzman
羟基磷灰石晶体在骨的机械承重性能中起着关键作用，并作为钙（CA）的现成来源，以支持许多钙依赖性生物系统，并将血液离子钙维持在正常范围内。骨骼、肠道和肾脏在保证钙的体内平衡方面都起着重要的作用。促钙激素如甲状旁腺激素（PTH）、PTHrP和1，25-二羟维生素D3启动骨细胞骨吸收并增加骨重建的激活频率。骨中羟基磷灰石晶体的镁含量变化很大，主要在骨表面，其中一部分与细胞外液（ECF）镁平衡。在细胞中，镁作为辅助因子，调节许多重要的生物系统。ECF中镁的浓度接近细胞内环境的浓度。
The hydroxyapatite crystal plays a key role in the mechanical weight‐bearing properties of bone and serves as a ready source of calcium (CA) to support a number of calcium‐dependent biological systems and to maintain blood ionized calcium within the normal range. The skeleton, the gut, and the kidney each play a major role in assuring calcium homeostasis. Calciotropic hormones such as parathyroid hormone (PTH), PTHrP, and 1,25‐dihydroxyvitamin D3initiate osteoclastic bone resorption and increase the activation frequency of bone remodeling. Magnesium content of the hydroxyapatite crystal in bone varies widely and is mainly on the surface of bone where a portion is in equilibrium with extracellular fluid (ECF) magnesium. In the cells, magnesium serves as a cofactor and regulates a number of essential biological systems. The concentration of magnesium in the ECF approaches that of the intracellular environment.