Molecular changes and signaling events occurring in spermatozoa during epididymal maturation.
Molecular changes and signaling events occurring in spermatozoa during epididymal maturation.
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DOI：
10.1111/andr.12320
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发表时间：
2017-03
期刊：
影响因子：
4.5
通讯作者：
Visconti PE
中科院分区：
文献类型：
--
作者：
Gervasi MG;Visconti PE
离开睾丸后，精子还没有获得进行性运动的能力，不能使卵母细胞受精。为了具有受精能力，它们必须在雄性中经历附睾成熟过程，在雌性管道中经历获能过程。附睾成熟可以定义为附睾中精子发生的变化，这些变化使精子能够在雌性管道中获能。作为该过程的一部分，精子细胞经历一系列生化和生理变化，这些变化需要掺入来自附睾上皮的新分子，以及睾丸中精子发生期间合成的内源性蛋白质的翻译后修饰。这篇综述将集中在附睾成熟事件，重点是在最近的进展，了解这一过程的分子基础。
After leaving the testis, sperm have not yet acquired the ability to move progressively and are unable to fertilize oocytes. To become fertilization-competent they must go through an epididymal maturation process in the male, and capacitation in the female tract. Epididymal maturation can be defined as those changes occurring to sperm in the epididymis that render the sperm the ability to capacitate in the female tract. As part of this process, sperm cells undergo a series of biochemical and physiological changes that require incorporation of new molecules derived from the epididymal epithelium, as well as post-translational modifications of endogenous proteins synthesized during spermiogenesis in the testis. This review will focus on epididymal maturation events, with emphasis in recent advances in the understanding of the molecular basis of this process.