Red nucleus lesions disrupt the classically conditioned nictitating membrane response in rabbits
Red nucleus lesions disrupt the classically conditioned nictitating membrane response in rabbits
复制标题
红核损伤破坏了兔子的经典条件瞬膜反应
DOI：
10.1016/0166-4328(83)90043-8
复制
发表时间：
1983
影响因子：
2.7
通讯作者：
J. W. Moore
中科院分区：
文献类型：
--
作者：
M. E. Rosenfield;J. W. Moore
16只兔接受经典的右侧瞬膜反应的条件反射，使用CS音调和电刺激右眼作为US。单次电凝左侧大细胞红核内侧部分的射频损伤消除或严重降低了先前获得的条件反应。这一发现与条件反应的基本解剖学基础包括从小脑到对侧红核的回路，对侧红核反过来投射到桥脑运动神经元，介导防御性瞬膜反应的想法是一致的。
Sixteen rabbits received classical conditioning of the right nictitating membrane response using a tone CS and electrostimulation of the right eye as the US. Single electrocoagulating RF lesions of the medial portion of the left magnocellular red nucleus eliminated or severely reduced the previously acquired conditioned response. This finding is consistent with the idea that an essential anatomical substrate of the conditioned response includes a circuit from the cerebellum to the contralateral red nucleus which projects contralaterally in turn to pontine motoneurons mediating the defensive nictitating membrane response.