An australian audit of vaccination status in children and adolescents with inflammatory bowel disease
An australian audit of vaccination status in children and adolescents with inflammatory bowel disease
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DOI：
10.1186/1471-230x-11-87
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发表时间：
2011-07-29
影响因子：
2.4
通讯作者：
Buttery, Jim P.
中科院分区：
文献类型：
--
作者：
Crawford, Nigel W.;Catto-Smith, Anthony G.;Buttery, Jim P.
背景：患有炎症性肠病（IBD）的儿童和青少年患疫苗可预防疾病（VPD）的风险增加。这包括侵袭性肺炎球菌疾病和流感。本研究的主要目的是描述诊断患有 IBD 的儿童和青少年是否遵守澳大利亚现行疫苗接种指南。第二个目的是审查 VPD 的血清学筛查。方法：从澳大利亚维多利亚州小儿炎症性肠病登记处随机抽取患者样本（诊断时 0-18 岁）。对免疫状况进行了多方面的回顾性审查，审核了医院记录，与同意的父母进行了电话访谈调查，并根据初级保健医生和澳大利亚儿童免疫登记册（ACIR）记录检查了疫苗接种史。澄清了常规的初级儿童疫苗接种以及推荐的额外流感和肺炎球菌疫苗的接种。结果：2007 年的审计审查了维多利亚州儿科 IBD 数据库中 101 个人的免疫状况。诊断时的中位年龄为 12.1 岁，50% 正在接受积极的免疫抑制治疗。 90% (38/42) [95% 置信区间 (CI) 77%； 97%]拥有完整的免疫信息，并进行了最新的常规初次免疫。仅 5% (5/101) [95% CI 2%； 11%] 接受了推荐的肺炎球菌疫苗加强疫苗，10% (10/101) [95% CI 5%； 17%] 有证据表明曾经接种过季节性流感疫苗。生活在维多利亚州农村地区 (p = 0.005) 以及诊断年龄较小 (p = 0.002) 的人更有可能曾经接种过流感疫苗。血清学检测回顾了 VPD 的历史保护情况，发现 18% (17/94) 的人有至少一份血清学样本的证据。结论：这项研究强调了 IBD 患者对其他推荐疫苗的依从性较差。需要采取多方面的方法来最大限度地保护这一脆弱的特殊风险人群免受 VPD 的影响。
Background: Children and adolescents with inflammatory bowel disease (IBD) are at increased risk of vaccine preventable diseases (VPD). This includes invasive pneumococcal disease and influenza. The primary aim of this study was to describe compliance with current Australian guidelines for vaccination of children and adolescents diagnosed with IBD. A secondary aim was to review the serological screening for VPD.Methods: A random sample of patients (0-18 years at diagnosis), were selected from the Victoria Australia state based Pediatric Inflammatory Bowel Disease Register. A multi-faceted retrospective review of immunization status was undertaken, with hospital records audited, a telephone interview survey conducted with consenting parents and the vaccination history was checked against the primary care physician and Australian Childhood Immunization Register (ACIR) records. The routine primary childhood vaccinations and administration of the recommended additional influenza and pneumococcal vaccines was clarified.Results: This 2007 audit reviewed the immunization status of 101individuals on the Victorian Pediatric IBD database. Median age at diagnosis was 12.1 years, 50% were on active immunosuppressive therapy. 90% (38/42) [95% confidence intervals (CI) 77%; 97%] with complete immunization information were up-to-date with routine primary immunizations. Only 5% (5/101) [95% CI 2%; 11%] received a recommended pneumococcal vaccine booster and 10% (10/101) [95% CI 5%; 17%] had evidence of having ever received a seasonal influenza vaccine. Those living in rural Victoria (p = 0.005) and younger at the age of diagnosis (p = 0.002) were more likely to have ever received an influenza vaccine Serological testing, reviewing historical protection from VPD, identified 18% (17/94) with evidence of at least one serology sample.Conclusion: This study highlights poor compliance in IBD patients for additional recommended vaccines. A multifaceted approach is required to maximize protection from VPD in this vulnerable special risk population.