Age-related changes in neural activity during performance matched working memory manipulation
Age-related changes in neural activity during performance matched working memory manipulation
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DOI：
10.1016/j.neuroimage.2008.06.021
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发表时间：
2008-10-01
期刊：
影响因子：
5.7
通讯作者：
Braver, Todd S.
中科院分区：
文献类型：
--
作者：
Emery, Lisa;Heaven, Timothy J.;Braver, Todd S.
认知老化文献中的一个长期假设是，涉及系列回忆的工作记忆（WM）任务的表现相对不受年龄的影响，而需要在回忆之前重新排列项目的任务更年龄敏感。以前的WM神经影像学研究发现，在简单的维护任务中，额顶叶脑区的神经活动与年龄相关的增加，但很少有人研究是否有年龄相关的差异，具体到重新安排WM项目。在目前的研究中，老年人和年轻人的大脑活动使用功能性磁共振成像（fMRI）进行监测，因为他们执行WM任务，包括维护或操作（字母-数字排序）。开发的范例，使性能是等效的跨年龄组在这两个任务，操作条件是不是更困难的维护条件。在年轻的成年人中，操作相关的激活增加在典型的大脑WM网络中的一组非常集中的区域内，包括左后前额叶皮层和双侧下顶叶皮层。与此相反，老年人表现出更广泛的范围内，这个WM网络的操纵相关的激活，与显着增加的活动相对于年轻的成年人发现在双边PFC。结果表明，激活和年龄的差异，在WM操作条件下的横向PFC参与可能反映策略的使用和控制处理的要求，而不是反映操作本身的行为。(C)2008年由Elsevier Inc.出版
A long-standing assumption in the cognitive aging literature is that performance on working memory (WM) tasks involving serial recall is relatively unaffected by aging, whereas tasks that require the rearrangement of items prior to recall are More age-sensitive. Previous neuroimaging Studies of WM have found age-related increases in neural activity in frontoparietal brain regions during simple maintenance tasks, but few have examined whether there are age-related differences that are specific to rearranging WM items. In the current Study, older and younger adults' brain activity was monitored using functional magnetic resonance imaging (fMRI) as they performed WM tasks involving either maintenance or manipulation (letter-number sequencing). The paradigm was developed so that performance was equivalent across age groups in both tasks, and the manipulation condition was not more difficult than the maintenance condition. In younger adults, manipulation-related increases in activation Occurred within a very focal set of regions within the canonical brain WM network, including left posterior prefrontal cortex and bilateral inferior parietal cortex. in contrast, older adults showed a much wider extent of manipulation-related activation within this WM network, with significantly increased activity relative to Younger adults found within bilateral PFC. The results suggest that activation and age-differences in lateral PFC engagement during WM manipulation conditions may reflect strategy use and controlled processing demands rather than reflect the act of manipulation per se. (C) 2008 Published by Elsevier Inc.