The United States national prospective hemolytic uremic syndrome study: Microbiologic, serologic, clinical, and epidemiologic findings
The United States national prospective hemolytic uremic syndrome study: Microbiologic, serologic, clinical, and epidemiologic findings
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DOI：
10.1086/319269
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发表时间：
2001-04-01
影响因子：
6.4
通讯作者：
Wells, JG
中科院分区：
文献类型：
--
作者：
Banatvala, N;Griffin, PM;Wells, JG
在美国儿童和成人中，产滋贺毒素大肠杆菌（STEC）血清型与肾后溶血性尿毒综合征（HUS）病例相关的频率，以及具有抗大肠杆菌脂多糖IgM或IgG抗体的比例。1987年1月至1991年12月对全国范围内的大肠杆菌O157进行了检测。在83名患者中，从70名粪便培养产生细菌生长的患者中的30名（43%）中分离出STEC（25名E。coli O157分离株和5株非O157 STEC分离株）。66例患者血清样本中有53例（80%）O157脂多糖抗体滴度阳性。在83名患者中，60名（72%）有STEC感染的证据，包括8名成人中的6名，他们的疾病也符合血栓性血小板减少性紫癜的标准。来自一个患者子集的数据表明，E。大肠杆菌O157是大于或等于80%的STEC感染的原因。所有3名产后妇女都有E。coliO157感染。STEC感染应被认为是所有产后HUS患者的可能原因。
The frequency of Shiga toxin-producing Escherichia coli (STEC) serotypes associated with postdiarrheal hemolytic uremic syndrome (HUS) cases among children and adults in the United States and the proportion with IgM or IgG lipopolysaccharide antibodies to E. coli O157 were determined by use of a nationwide sample from January 1987 through December 1991. Among 83 patients, STEC were isolated from 30 (43%) of 70 whose stool cultures yielded bacterial growth (25 E. coli O157 isolates and 5 non-O157 STEC isolates). Fifty-three (80%) of 66 patients with serum samples had positive O157 lipopolysaccharide antibody titers. Of the 83 patients, 60 (72%) had evidence of STEC infection, including 6 of 8 adults whose illnesses also met criteria for thrombotic thrombocytopenic purpura. Data from a subset of patients suggest that E. coli O157 was the cause of greater than or equal to 80% of the STEC infections. All 3 women who were postpartum had evidence of E. coli O157 infection. STEC infection should be considered the likely cause for all persons with postdiarrheal HUS.