The Natural History and Rehabilitative Outcomes of Hearing Loss in Congenital Cytomegalovirus: A Systematic Review.
The Natural History and Rehabilitative Outcomes of Hearing Loss in Congenital Cytomegalovirus: A Systematic Review.
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DOI：
10.1097/mao.0000000000001861
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发表时间：
2018-08
期刊：
影响因子：
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通讯作者：
Bush ML
中科院分区：
文献类型：
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作者：
Fletcher KT;Horrell EMW;Ayugi J;Irungu C;Muthoka M;Creel LM;Lester C;Bush ML
这项研究的目的是审查有关先天性巨细胞病毒感染所致感音神经性听力损失的自然病史和康复结果的文献。我们在PubMed、心理学信息、CINAHL和科学网上进行了系统的搜索，以确定同行评议的研究。符合条件的研究是那些包含最初的同行评议的英文研究，涉及CCMV中SNHL的自然历史或康复结果。两名调查人员独立审阅了所有文章并提取了数据。使用Cochrane Collaboration的工具和纽卡斯尔-渥太华评估量表对偏差进行评估。对36篇文献进行综述。全民筛查发现0.2-1%的新生儿感染CCMV。SNHL在婴儿中的比例为8%-32%，在有症状的病例中比无症状的病例更常见。9-68%的听力损失是以迟发性或延迟性的方式发生的。在7-71%的病例中，听力损失是进行性的。人工耳蜗术是CCMV相关性听力损失患者的一种可行的选择，并能改善听力和语言。比较CCMV和非CCMV CI接受者康复效果的文献有限。迟发性和进行性听力损失见于CCMV导致听力损失的儿童。考虑到CCMV听力损失的自然病史，频繁的听力学随访是必要的。应根据出生时无症状儿童的数量进行普遍筛查，这些儿童在出生时出现迟发性/迟发性听力损失。人工耳蜗术是改善这一人群言语和语言的有效手段。
The purpose of this study was to examine the literature regarding the natural history and rehabilitative outcomes of sensorineural hearing loss from congenital cytomegalovirus infections. A systematic search was performed in PubMed, PsychINFO, CINAHL, and Web of Science to identify peer-reviewed research. Eligible studies were those containing original peer-reviewed research in English addressing either the natural history or rehabilitative outcomes of SNHL in cCMV. Two investigators independently reviewed all articles and extracted data. Bias was assessed using the Cochrane Collaboration’s tool and the Newcastle-Ottawa Assessment Scale. Thirty-six articles were reviewed. Universal screening identifies 0.2 – 1% of newborns with cCMV infection. SNHL ranged from 8–32% of infants and was more prevalent in symptomatic vs. asymptomatic cases. 9 – 68% of hearing loss occurs in a late or delayed fashion. In 7–71% of cases hearing loss is progressive. Cochlear implantation is a viable option for patients with cCMV associated hearing loss and leads to improvements in hearing and language. There is limited literature comparing rehabilitation outcomes in cCMV and non-cCMV CI recipients. Late onset and progressive hearing loss is seen in children who develop hearing loss from cCMV. Frequent audiologic follow-up is necessary considering the natural history of cCMV hearing loss. Universal screening should be pursued due to the number of asymptomatic children, at birth, who develop late onset/delayed hearing loss. Cochlear implantation is an effective means of improving speech and language in this population.