Anatomical correlates of sentence comprehension and verbal working memory in neurodegenerative disease
Anatomical correlates of sentence comprehension and verbal working memory in neurodegenerative disease
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DOI：
10.1523/jneurosci.1331-07.2007
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发表时间：
2007-06-06
影响因子：
5.3
通讯作者：
Gorno-Tempini, Maria Luisa
中科院分区：
文献类型：
--
作者：
Amici, Serena;Brambati, Simona M.;Gorno-Tempini, Maria Luisa
本研究调查句子理解和非句法言语工作记忆（vWM）是否由相同或不同的神经系统维持。在 58 名神经退行性疾病患者中，使用基于体素的形态测量法，将句子-图片匹配任务和数字向后 (DB) 的得分与磁共振成像体素灰质体积相关联。结果表明，无论语法结构如何，总体句子理解得分与左侧颞顶叶区域的灰质体积相关，而 DB 得分与背外侧前额叶和下顶叶体积相关。多子句关系句子（类型 3）的理解与左额下回和额中回背侧部分的体素显着相关。当直接比较 DB 和多子句关系句子时，它们在左额叶背外侧区域显示出重叠的神经基质，支持句法和非句法任务的 vWM 的单一来源。在这个共同参与的大区域中，三角部的一小部分显示出多分句句子的独立作用，而额中回的一个区域显示出与 DB 更大的相关性。这项研究调和了两种相反的观点，即句子理解和 vWM 依赖于相同或不同的解剖资源。
This study investigates whether sentence comprehension and nonsyntactic verbal working memory (vWM) are sustained by the same or by different neural systems. Scores in a sentence-picture matching task and in digits backward (DB) were correlated with magnetic resonance imaging voxelwise gray matter volumes using voxel-based morphometry in 58 patients with neurodegenerative diseases. Results showed that overall sentence comprehension scores, regardless of grammatical structure, correlated with gray matter volumes in the left temporoparietal region, whereas DB scores correlated with dorsolateral prefrontal and inferior parietal volumes. Comprehension of multiclausal relative sentences (type 3) significantly correlated with voxels in the dorsal portion of the left inferior and middle frontal gyri. When DB and multiclausal relative sentences were directly compared, they showed overlapping neural substrates in the dorsolateral left frontal region, supporting a single source of vWM for syntactic and nonsyntactic tasks. Within this large area of common involvement, a small portion of pars triangularis showed an independent effect of multiclausal sentences, whereas a region in the middle frontal gyrus showed greater correlation with DB. This study reconciles two opposing views, which hold that sentence comprehension and vWM rely on either the same or different anatomical resources.