Inequality in function of the right and left ovaries and uterine horns of the mouse.
Inequality in function of the right and left ovaries and uterine horns of the mouse.
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小鼠左右卵巢和子宫角功能不平等。
DOI：
10.1530/jrf.0.0790125
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
W. C. Becker
中科院分区：
文献类型：
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作者：
J. Wiebold;W. C. Becker
在三个独立的实验中评价了小鼠左右卵巢和子宫角功能的不平等。在Exp. 1.用158只孕鼠观察了不同位置对不同生殖器官的影响。妊娠第18天（阴道栓=第1天），右侧的排卵率、胎仔数、胎仔总重量和胎盘总重量高于左侧（P <0.05）。在Exp.在图2中，将交配的Swiss-Webster小鼠中先前假手术或单侧卵巢切除术（右侧或左侧）的效果与未手术的交配对照（N = 17-24/处理）进行比较。对照组小鼠右侧排卵率、胎儿总重量和卵巢重量均高于左侧（P <0.05）。手术（假手术或单侧卵巢切除术）降低了妊娠第18天的排卵率、胎儿数量、卵巢重量、胎儿总重量和胎盘总重量（P <0.005）。单侧卵巢切除组排卵率和卵巢重量较假手术组明显降低（P <0.05）。左侧卵巢切除组排卵率高于右侧卵巢切除组（P <0.01）。用于实验3，将每对8个杂交小鼠胚胎（桑椹胚和囊胚）手术转移到相同（双侧，N = 15）或不同（单侧，N = 28）Swiss-Webster受体的左右子宫角。在几乎所有的发生率中，右侧子宫角的胚胎存活率（至妊娠第18天）是左侧子宫角的两倍（P <0.05）。我们的结论是，左右卵巢和子宫角是不平等的功能在瑞士韦伯斯特和杂交品系的小鼠。
Inequality in function of the left and right ovaries and uterine horns of mice was evaluated in three separate experiments. In Exp. 1, the effect of position in the reproductive tract on various reproductive characteristics was evaluated in 158 pregnant hybrid mice. Ovulation rate, number of fetuses, total fetal weight and total placental weight were higher (P less than 0.05) on the right than the left on Day 18 of pregnancy (vaginal plug = Day 1). In Exp. 2, the effect of previous sham or unilateral ovariectomy (right or left) in mated Swiss-Webster mice was compared with unoperated mated controls (N = 17-24/treatment). In control mice, ovulation rate, total fetal weight and ovarian weight were higher (P less than 0.05) on the right than left side. Surgery (sham or unilateral, ovariectomy) decreased (P less than 0.005) ovulation rates, number of fetuses, ovarian weights, total fetal weight and total placental weight on Day 18 of pregnancy. Unilateral ovariectomy decreased (P less than 0.05) ovulation rates and ovarian weights more than did sham operation. Ovulation rates were higher (P less than 0.01) when the left ovary was manipulated or removed rather than the right ovary. For Exp. 3, pairs of 8 hybrid mouse embryos each (morulae and blastocysts) were surgically transferred to the left and right uterine horns of the same (bilateral, N = 15) or different (unilateral, N = 28) Swiss-Webster recipients. In almost all incidences, embryo survival (to Day 18 of pregnancy) was twice as high (P less than 0.05) in right than left uterine horns. We conclude that the left and right ovaries and uterine horns are not equal in function in Swiss-Webster and a hybrid strain of mice.