Association between dietary phyto-oestrogens and bone density in men and postmenopausal women
Association between dietary phyto-oestrogens and bone density in men and postmenopausal women
复制标题
DOI：
10.1017/s0007114511001309
复制
发表时间：
2011-10-01
影响因子：
3.6
通讯作者：
Khaw, Kay-Tee
中科院分区：
文献类型：
--
作者：
Kuhnle, Gunter G. C.;Ward, Heather A.;Khaw, Kay-Tee
植物雌激素与骨质疏松症风险降低有关，但西方国家干预和观察性研究的结果并不一致。在本研究中，我们研究了习惯性植物雌激素摄入与跟骨宽带超声衰减（BUA）之间的关系，后者是骨密度的标志。我们收集了欧洲癌症-诺福克研究前瞻性调查参与者（45-75岁）7天的饮食记录、病史、人口统计和人体测量数据。植物雌激素（生物茶素A、大豆苷元、刺芒柄花素、染料木素、糖苷、松脂醇、次异松脂醇、肠内酯、马雌酚）的摄入量使用新开发的食品成分数据库进行测定。用跟骨BUA测定骨密度。研究人员对2580名未接受激素替代治疗的绝经后妇女和4973名男性进行了骨密度和植物雌激素摄入之间的关系调查。绝经后女性总植物雌激素的中位摄入量为876 μ g/d（四分位数范围为412），男性为1212 μ g/d（四分位数范围为604）。非大豆异黄酮刺芒柄花素和生物茶素A与绝经后妇女的BUA有轻微或显著相关(β = 1.2； P
Phyto-oestrogens have been associated with a decreased risk for osteoporosis, but results from intervention and observational studies in Western countries have been inconsistent. In the present study, we investigated the association between habitual phyto-oestrogen intake and broadband ultrasound attenuation (BUA) of the calcanaeum as a marker of bone density. We collected 7 d records of diet, medical history and demographic and anthropometric data from participants (aged 45-75 years) in the European Prospective Investigation into Cancer-Norfolk study. Phyto-oestrogen (biochanin A, daidzein, formononetin; genistein, glycitein; matairesinol; secoisolariciresinol; enterolactone; equol) intake was determined using a newly developed food composition database. Bone density was assessed using BUA of the calcanaeum. Associations between bone density and phyto-oestrogen intake were investigated in 2580 postmenopausal women who were not on hormone replacement therapy and 4973 men. Median intake of total phyto-oestrogens was 876 (interquartile range 412) mu g/d in postmenopausal women and 1212 (interquartile range 604) mu g/d in men. The non-soya isoflavones formononetin and biochanin A were marginally significant or significantly associated with BUA in postmenopausal women (beta = 1.2; P