Quantitative fMRI using hyperoxia calibration: Reproducibility during a cognitive Stroop task
Quantitative fMRI using hyperoxia calibration: Reproducibility during a cognitive Stroop task
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DOI：
10.1016/j.neuroimage.2009.04.064
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发表时间：
2009-08-15
期刊：
影响因子：
5.7
通讯作者：
Parkes, Laura M.
中科院分区：
文献类型：
--
作者：
Goodwin, Jonathan A.;Vidyasagar, Rishma;Parkes, Laura M.
动脉自旋标记可以同时测量血氧水平依赖性 (BOLD) 和脑血流量 (CBF) 对神经活动变化的反应。添加高碳酸血症或高氧血症校准可以对脑氧代谢率 (CMRO2) 的变化进行额外量化。在这项研究中，我们测试了在认知斯特鲁普任务期间使用高氧方法得出的测量结果的再现性。使用 QUIPSSII 序列在 3 T 下收集两个 3 分钟高氧期和 8 分钟 Stroop 任务期间同时的 CBF 和 BOLD 信号。通过开放系统进行高氧治疗，并通过鼻插管对潮气末值进行采样；平均潮末值达到 60%。重复该过程以测试估计参数的再现性。使用认知斯特鲁普任务可以测试额叶和顶叶区域以及先前研究重点的感觉运动区域的测量结果。我们发现与高碳酸血症方法相比，计算参数的再现性降低，这被认为是由于绝对 BOLD 和 CBF 响应较低。特别是，我们没有发现“n”与其他参数相比具有改进的重现性，正如在之前使用高碳酸血症方法的工作中发现的那样。在所有大脑区域中，我们报告 Delta CMRO2 值为 12%，神经血管耦合常数 n 为 2.5。有趣的是，我们发现与初级运动皮层相比，顶叶和额叶区域的 n 更高。 (C) 2009 Elsevier Inc. 保留所有权利。
Arterial spin labelling allows simultaneous measurement of both the blood-oxygenation-level-dependent (BOLD) and the cerebral blood flow (CBF) response to changes in neural activity. The addition of a hypercapnia or hyperoxia calibration allows additional quantification of changes in the cerebral metabolic rate of oxygen (CMRO2). In this study we test the reproducibility of measurements derived using the hyperoxia approach, during a cognitive Stroop task. A QUIPSSII sequence is used at 3 T to collect simultaneous CBF and BOLD signal during two 3 min periods of hyperoxia and an 8 min Stroop task. Hyperoxia was administered via an open system and end-tidal values were sampled via a nasal cannula; average end-tidal values of 60% were reached. This procedure is repeated to allow the reproducibility of the estimated parameters to be tested. The use of a cognitive Stroop task allows testing of the measurements in frontal and parietal regions as well as sensorimotor areas in which previous studies have been focussed. We find reduced reproducibility of the Calculated parameters compared to the hypercapnia approach, thought to be attributable to lower absolute BOLD and CBF responses. In particular we do not find 'n' to have improved reproducibility compared to other parameters, as has been found in previous work using the hypercapnia approach. Across all brain areas we report a value of Delta CMRO2 of 12% and neurovascular coupling constant n of 2.5. Interestingly we find n to be higher in parietal and frontal areas in comparison to the primary motor cortex. (C) 2009 Elsevier Inc. All rights reserved.