Major cell death pathways at a glance
Major cell death pathways at a glance
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DOI：
10.1016/j.micinf.2009.08.013
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发表时间：
2009-11-01
影响因子：
5.8
通讯作者：
Vandenabeele, Peter
中科院分区：
文献类型：
--
作者：
Duprez, Linde;Wirawan, Ellen;Vandenabeele, Peter
细胞死亡是多细胞生物体发育、稳态和免疫调节的重要过程，其失调与多种病理学相关。作为防御机制的一部分，细胞死亡通常在病原体感染时被诱导，并且病原体已经进化出调节宿主细胞死亡的策略。在这篇综述中，我们将讨论四种主要类型的程序性细胞死亡，即细胞凋亡的分子机制和生理相关性。坏死、自噬性细胞死亡和焦亡。(C)2009年Elsevier Masson SAS。All rights reserved.
Cell death is a crucial process during development, homeostasis and immune regulation of multicellular organisms, and its dysregulation is associated with numerous pathologies. Cell death is often induced upon pathogen infection as part of the defense mechanism, and pathogens have evolved strategies to modulate host cell death. In this review, we will discuss the molecular mechanisms and physiological relevance of four major types of programmed cell death, namely apoptosis. necrosis, autophagic cell death and pyroptosis. (C) 2009 Elsevier Masson SAS. All rights reserved.