The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury
The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury
复制标题
DOI：
10.1016/j.neuron.2005.03.003
复制
发表时间：
2005-04-21
期刊：
影响因子：
16.2
通讯作者：
Tuszynski, MH
中科院分区：
文献类型：
--
作者：
Conner, JM;Chiba, AA;Tuszynski, MH
皮质代表的重组被认为是许多类型神经系统损伤后功能恢复的基础。这种皮层可塑性的神经元机制尚不清楚。本研究探讨了这样的假设：基底前脑胆碱能系统在脑损伤后功能恢复所需的皮质重组中发挥着重要作用。结果表明，皮质损伤后的功能恢复需要基底前脑胆碱能机制，并建议这种恢复的基础是胆碱能依赖性重组的电机代表。这些发现提出了一个有趣的可能性，即胆碱能功能的缺陷可能会限制神经系统损伤后的功能结果。
A reorganization of cortical representations is postulated as the basis for functional recovery following many types of nervous system injury. Neuronal mechanisms underlying this form of cortical plasticity are poorly understood. The present study investigated the hypothesis that the basal forebrain cholinergic system plays an essential role in enabling the cortical reorganization required for functional recovery following brain injury. The results demonstrate that functional recovery following cortical injury requires basal forebrain cholinergic mechanisms and suggest that the basis for this recovery is the cholinergic-dependent reorganization of motor representations. These findings raise the intriguing possibility that deficits in cholinergic function may limit functional outcomes following nervous system injury.