Intramolecular hydroamination of unactived olefins with Ti(NMe2)4 as a precatalyst
Intramolecular hydroamination of unactived olefins with Ti(NMe2)4 as a precatalyst
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DOI：
10.1021/ol0503992
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发表时间：
2005-05-12
期刊：
影响因子：
5.2
通讯作者：
Schafer, LL
中科院分区：
文献类型：
--
作者：
Bexrud, JA;Beard, JD;Schafer, LL
[图形]工业上可获得的Ti(NMe2)(4)已被有效地用作预催化剂，用于氨基烯的分子内氢胺化反应，生成吡咯烷和哌啶杂环产品，分离收率高达92%。生殖细胞取代的底物表现出最高的反应活性。这种预催化剂对活化的内部烯烃的氢胺化反应也很有效，提供了获得更复杂的杂环目标分子的途径。
[GRAPHICS]Commercially available Ti(NMe2)(4) has been used effectively as a precatalyst in a facile protocol for the intramolecular hydroamination of aminoalkenes to yield pyrrolidine and piperidine heterocyclic products with isolated yields up to 92%. Germinally substituted substrates display the highest reactivity. This precatalyst is also effective for the hydroamination of activated internal alkenes, providing access to more complex heterocyclic target molecules.