Short communication: breast parenchymal patterns and their changes with age.
Short communication: breast parenchymal patterns and their changes with age.
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简短的交流：乳房实质模式及其随年龄的变化。
DOI：
10.1259/0007-1285-68-814-1133
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Jan H. C. L. Hendriks
中科院分区：
文献类型：
--
作者：
C. H. Gils;J. Otten;A.L.M. Verbeek;Jan H. C. L. Hendriks
在关于大规模筛查的研究中，经常有报告称，具有致密实质的乳房肿瘤难以检测，并且在诊断时可能处于更晚期。对于这些女性，建议缩短再筛查间隔，但在推荐这种策略之前，重要的是调查致密乳腺实质（Wolfe的P2和DY模式）在筛查人群中实际存在的频率以及这些模式随年龄变化的程度。在我们的研究人群中，首次检查时致密乳腺实质（P2和DY）的患病率为33%（n = 2581），与其他筛查人群相比相当低。它的存在是强烈的，反向年龄依赖。对1177名年龄在35-85岁之间的女性的乳房模式进行了12年的跟踪。在39%（182/461）首次检查时为P2或DY模式的女性中，多年来发生了消退至透明模式（N1和P1）。假设这些妇女中的大多数在随访期间已经达到绝经期。这些发现支持了致密乳腺实质的存在与生殖期有关的假设，并表明缩短再筛查间隔在绝经前年龄组中最有效。
In studies on mass screening, it has often been reported that tumours in breasts with dense parenchyma are difficult to detect and may have a more advanced stage at diagnosis. Shorter rescreening intervals have been suggested for these women but, before recommending such a strategy, it is important to investigate how often dense breast parenchyma (P2 and DY patterns according to Wolfe) is actually present in a screening population and to what extent these patterns change with age. The prevalence of dense breast parenchyma (P2 and DY) in our study population was 33% at first examination (n = 2581), which is fairly low compared with other screening populations. Its presence was strongly, inversely age-dependent. Breast patterns of 1177 women, aged 35-85 years, were followed for 12 years. In 39% (182/461) of the women with a P2 or DY pattern at their first examination, regression to a lucent pattern (N1 and P1) occurred over the years. The majority of these women were assumed to have reached menopause in the follow-up period. These findings support the hypothesis that the presence of dense breast parenchyma is related to the reproductive period and indicate that shortening the rescreening intervals would be most effective in pre-menopausal age groups.