Adiposity and Alzheimer's disease.
Adiposity and Alzheimer's disease.
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DOI：
10.1097/mco.0b013e32831c8c71
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发表时间：
2009-01
影响因子：
3.1
通讯作者：
Gustafson DR
中科院分区：
文献类型：
--
作者：
Luchsinger JA;Gustafson DR
阿尔茨海默病（AD）是痴呆症最常见的形式。没有已知的预防或治疗措施。有越来越多的证据表明，总肥胖的作用，通常在临床上测量体重指数（BMI），和中心性肥胖，在AD中测量。鉴于全球高脂肪流行及其后果，这一主题具有巨大的公共卫生重要性。2007年和2008年的重要出版物表明，a）中年中心性肥胖预测老年痴呆; B）高肥胖和痴呆之间的关系随着年龄的增长而减弱; c）老年腰围，中心性肥胖的测量，可能是比BMI更好的痴呆预测因子，d）较低的BMI预测老年痴呆; e）体重减轻可能比痴呆症诊断早几十年，这可能解释了看似矛盾的发现。考虑到一般人群超重和肥胖的全球趋势，高肥胖增加AD风险的可能性令人担忧。然而，预防和控制肥胖也可能提供预防AD的方法。AD患者的减肥治疗也可能很重要，但超出了本综述的范围。
Alzheimer’s disease (AD) is the most common form of dementia. There are no known preventive or curative measures. There is increasing evidence for the role of total adiposity, usually measured clinically as body mass index (BMI), and central adiposity, measured in AD. This topic is of enormous public health importance given the global epidemic of high adiposity and its consequences. Salient publications in 2007 and 2008 showed that a) central adiposity in middle age predicts dementia in old age; b) the relation between high adiposity and dementia is attenuated with older age; c) waist circumference in old age, a measure of central adiposity, may be a better predictor of dementia than BMI, d) lower BMI predicts dementia in the elderly; e) weight loss may precede dementia diagnosis by decades, which may explain seemingly paradoxical findings. The possibility that high adiposity increases AD risk is alarming given global trends of overweight and obesity in the general population. However, prevention and manipulation of adiposity may also provide a means to prevent AD. Treatment of weight loss in AD may also be important but is beyond the score of this review.