Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota
Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota
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DOI：
10.1073/pnas.1107857108
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发表时间：
2011-10-18
影响因子：
11.1
通讯作者：
Baeumler, Andreas J.
中科院分区：
文献类型：
--
作者：
Thiennimitr, Parameth;Winter, Sebastian E.;Baeumler, Andreas J.
传统观点认为，微生物通过利用各种各样的营养物质来支持它们在脊椎动物宿主中的生长。我们在这里表明，使用特定的营养素（乙醇胺）赋予显着的增长优势，沙门氏菌肠道血清型鼠伤寒（S。在发炎的肠腔中。在肠道的厌氧环境中，乙醇胺很少或根本不支持发酵生长。然而，S.鼠伤寒能够通过诱导肠道产生呼吸电子受体（连四硫酸盐）来利用这种碳源，该受体支持乙醇胺上的厌氧生长。肠道通常将周围的硫化氢转化为硫代硫酸盐，然后在炎症期间进一步氧化为连四硫酸盐。有证据表明，S。鼠伤寒沙门氏菌在发炎肠道中的生长优势是因为它能够呼吸乙醇胺，乙醇胺从宿主组织中释放出来，但不能被竞争细菌利用。S.鼠伤寒回避营养竞争，并获得使用宿主提供的丰富的简单底物乙醇胺的能力。
Conventional wisdom holds that microbes support their growth in vertebrate hosts by exploiting a large variety of nutrients. We show here that use of a specific nutrient (ethanolamine) confers a marked growth advantage on Salmonella enterica serovar Typhimurium (S. Typhimurium) in the lumen of the inflamed intestine. In the anaerobic environment of the gut, ethanolamine supports little or no growth by fermentation. However, S. Typhimurium is able to use this carbon source by inducing the gut to produce a respiratory electron acceptor (tetrathionate), which supports anaerobic growth on ethanolamine. The gut normally converts ambient hydrogen sulfide to thiosulfate, which it then oxidizes further to tetrathionate during inflammation. Evidence is provided that S. Typhimurium's growth advantage in an inflamed gut is because of its ability to respire ethanolamine, which is released from host tissue, but is not utilizable by competing bacteria. By inducing intestinal inflammation, S. Typhimurium sidesteps nutritional competition and gains the ability to use an abundant simple substrate, ethanolamine, which is provided by the host.