Differences between concentrations of salivary cortisol and cortisone and of free cortisol and cortisone in plasma during pregnancy and postpartum.
Differences between concentrations of salivary cortisol and cortisone and of free cortisol and cortisone in plasma during pregnancy and postpartum.
复制标题
妊娠和产后唾液皮质醇和可的松浓度与血浆中游离皮质醇和可的松浓度的差异。
作者：
P. Meulenberg;J A Hofman
我们测量了怀孕期间和产后血浆中的皮质醇和可的松（包括总的和游离的）以及唾液中的皮质醇和可的松。产前和产后的浓度和上午和下午的浓度进行了比较。皮质醇和可的松的平均浓度增加对术语和显着大于在妊娠结束时比产后，除了在下午血浆中的游离皮质醇。两种类固醇的每日节律在整个妊娠期和产后保持不变。唾液和血浆游离浓度的皮质醇和可的松以及皮质醇+可的松的总和之间的相关性非常显着。唾液中可的松的平均浓度准确地反映了血浆中的总浓度和游离浓度。唾液中皮质醇浓度的变化与血浆中皮质醇浓度的变化有一定差异。此外，血浆游离皮质醇与唾液皮质醇的质量比约为2，而可的松的质量比仅约为0.5，这可能是由于唾液腺中的11 β-羟基类固醇脱氢酶将皮质醇转化为可的松。此外，皮质醇和可的松从血浆到唾液的通道不应被视为简单的扩散，因为在怀孕的前半期，唾液中皮质醇+可的松的浓度之和明显超过血浆中游离浓度之和。
We measured cortisol and cortisone in plasma--both total and free--and in saliva during the course of pregnancy and postpartum. Antepartum and postpartum concentrations and morning and afternoon concentrations of both steroids were compared. The mean concentrations of cortisol and cortisone increased towards term and were significantly greater at the end of pregnancy than postpartum, except for free cortisol in plasma in the afternoon. The daily rhythm of both steroids was maintained throughout pregnancy and postpartum. The correlations between salivary and plasma free concentrations of cortisol and cortisone as well as of the sum of cortisol + cortisone were highly significant. The mean concentrations of cortisone in saliva accurately reflected both total and free concentrations in plasma. For cortisol, however, the change of the concentrations in saliva, was somewhat different from that in plasma. Moreover, the mass ratio of plasma free cortisol to salivary cortisol was about 2, whereas for cortisone the ratio was only about 0.5, probably owing to the conversion of cortisol to cortisone by 11 beta-hydroxysteroid dehydrogenase in the salivary gland. Furthermore, the passage of cortisol and cortisone from plasma to saliva should not be regarded as simple diffusion, because in the first half of pregnancy the sum of the concentrations of cortisol + cortisone in saliva significantly exceeded the sum of their free concentrations in plasma.