The Efficacy and Safety of Balloon Enteroscopy-Assisted Endoscopic Retrograde Cholangiography in Pediatric Patients with Surgically Altered Gastrointestinal Anatomy.

The Efficacy and Safety of Balloon Enteroscopy-Assisted Endoscopic Retrograde Cholangiography in Pediatric Patients with Surgically Altered Gastrointestinal Anatomy.
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DOI:
10.3390/jcm10173936
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发表时间:
2021-08-31
影响因子:
3.9
通讯作者:
Yamamoto H
Yamamoto H
中科院分区:
医学2区
文献类型:
--
作者:
Yokoyama K;Yano T;Kanno A;Ikeda E;Ando K;Miwata T;Nagai H;Kawasaki Y;Tada Y;Sanada Y;Tamada K;Lefor AK;Yamamoto H

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球囊小肠镜辅助逆行胆道造影术(BEA-ERC)在成人胰胆管疾病中是有效和可行的,但其在儿童患者中的有效性和安全性尚未确定。我们比较了成人和儿童患者BEA-ERC的成功率和安全性。这项单中心回顾研究回顾了2007年1月至2019年12月期间因胆道疾病而接受BEA-ERC治疗的348名胃肠解剖改变的患者(儿科:57例,成人:291例)。儿童患者十二指肠乳头吻合成功率显著低于成人患者(66.7%vs.88.0%,p<0.01)。儿科患者的临床成功率也明显较低(64.9%vs.80.4%,p=0.014)。儿童患者的不良事件发生率显著高于成人患者(14.2%vs.7.7%,p=0.037)。然而,如果到达儿童患者的吻合口,治疗是非常成功的(97.3%)。儿童患者到达靶点的时间明显长于成人患者。这项研究表明,儿童患者的BEA-ERC比成人患者更困难。然而,在气囊肠镜推进到吻合口的患者中,可以获得与成人相似的临床结果。
Balloon enteroscopy-assisted endoscopic retrograde cholangiography (BEA-ERC) is useful and feasible in adults with pancreatobiliary diseases, but its efficacy and safety have not been established in pediatric patients. We compared the success rate and safety of BEA-ERC between adults and pediatric patients. This single-center retrospective study reviewed 348 patients (pediatric: 57, adult: 291) with surgically altered gastrointestinal anatomies who underwent BEA-ERC for biliary disorders from January 2007 to December 2019. The success rate of reaching the anastomosis or duodenal papilla was significantly lower in pediatric patients than in adult patients (66.7% vs. 88.0%, p < 0.01). The clinical success rate was also significantly lower in pediatric patients (64.9% vs. 80.4%, p = 0.014). The rate of adverse events was significantly higher in pediatric patients than in adults (14.2% vs. 7.7%, p = 0.037). However, if the anastomotic sites were reached in pediatric patients, the treatment was highly successful (97.3%). The time of reaching target site was significantly longer in pediatric patients than in adult patients. This study shows that BEA-ERC in pediatric patients is more difficult than that in adult patients. However, in patients where the balloon enteroscope was advanced to the anastomosis, clinical outcomes comparable to those in adults can be achieved.
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