DISCRETE SEQUENTIAL BOUNDARIES FOR CLINICAL-TRIALS
DISCRETE SEQUENTIAL BOUNDARIES FOR CLINICAL-TRIALS
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DOI：
10.2307/2336502
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发表时间：
1983-01-01
期刊：
影响因子：
2.7
通讯作者：
DEMETS, DL
中科院分区：
文献类型：
--
作者：
LAN, KKG;DEMETS, DL
Pocock（1977）、O''Brien和Fleming（1979）以及Slud和Wei（1982）提出了不同的方法来构建临床试验的离散序列边界。这些方法要求预先指定决策次数的总数。提出了一种更为灵活的离散序列边界构造方法。该方法基于函数α * 的选择。(t)，其表征误差水平α.已经耗尽了判定时间的边界由α * 确定。(t)，以及通过过去和当前的决策时间，但不依赖于未来的决策时间或决策时间的总数。
Pocock (1977), O''Brien and Fleming (1979) and Slud and Wei (1982) have proposed different methods to construct discrete sequential boundaries for clinical trials. These methods require that the total number of decision times be specified in advance. A more flexible way to construct discrete sequential boundaries is proposed. The method is based on the choice of a function, .alpha.*(t), which characterizes the rate at which the error level .alpha. is spent. The boundary at a decision time is determined by .alpha.*(t), and by past and current decision times, but does not depend on the future decision times or the total number of decision times.