Compliance with osteoporosis drug therapy and risk of fracture
Compliance with osteoporosis drug therapy and risk of fracture
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DOI：
10.1007/s00198-006-0230-y
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发表时间：
2007-03-01
影响因子：
4
通讯作者：
Oster, G.
中科院分区：
文献类型：
--
作者：
Weycker, D.;Macarios, D.;Oster, G.
介绍骨质疏松症药物治疗的患者依从性往往是穷人在临床实践中，并可能与较高的fraction.Methods的风险进行了巢式病例对照研究，使用美国健康保险索赔数据库。源人群包括所有年龄≥ 45岁开始骨质疏松症药物治疗的女性。病例包括那些经历过骨关节炎相关骨折的患者;他们与没有骨关节炎相关骨折的对照组相匹配。根据接受治疗天数和药物拥有率（MPR）评估骨质疏松症药物治疗的依从性。采用条件Logistic回归分析依从性与骨折风险之间的关系。结果共确定了453例糖尿病相关骨折的女性，并与2,160例对照组进行了匹配。治疗时间> 180天的患者骨折风险显著低于治疗时间> 180天的患者[181-360天：比值比（OR）= 0.70，95% CI = 0.49-0.99; > 360天：OR = 0.65，95% CI = 0.43-0.99]。
Introduction Patient compliance with osteoporosis drug therapy is often poor in clinical practice and may be associated with higher risk of fracture.Methods A nested case-control study was undertaken using a US health insurance claims database. The source population included all women aged >= 45 years who began drug therapy for osteoporosis. Cases consisted of those who experienced an osteoporosis-related fracture; they were matched to controls without osteoporosis-related fracture. Compliance with osteoporosis drug treatment was assessed in terms of the number of therapy-days received and medication possession ratio (MPR). Conditional logistic regression was employed to examine the relationship between compliance and fracture risk.Results A total of 453 women with osteoporosis-related fracture were identified and matched to 2,160 controls. Fracture risk was significantly lower for patients with > 180 days of therapy [181-360 days: odds ratio (OR) = 0.70, 95% CI = 0.49-0.99; > 360 days: OR = 0.65, 95% CI = 0.43-0.99) versus those with