Motivation and cognitive control in the human prefrontal cortex
Motivation and cognitive control in the human prefrontal cortex
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DOI：
10.1038/nn.2321
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发表时间：
2009-07-01
影响因子：
25
通讯作者：
Koechlin, Etienne
中科院分区：
文献类型：
--
作者：
Kouneiher, Frederique;Charron, Sylvain;Koechlin, Etienne
前额叶皮层（PFC）有助于认知控制，即选择与内部目标相关的想法或行动的能力。然而，关于前额叶皮层如何结合动机和认知控制下的选择过程，我们知之甚少。我们使用功能性磁共振成像在人类中，发现内侧和外侧PFC有一个平行的层次组织，从后到前的区域激励和选择行为，分别。此外，使用功能连接分析，我们发现，在这个平行的系统中，从内侧到外侧PFC区域的功能相互作用传递激励的奖励/惩罚的基础上，调节外侧PFC区域的差异参与自上而下的选择。我们的研究结果表明，动机是一个可分离的功能，揭示了如何PFC整合动机和认知控制的决策服务，并有重大影响，目前的理论前额叶执行功能。
The prefrontal cortex (PFC) subserves cognitive control, that is, the ability to select thoughts or actions in relation to internal goals. Little is known, however, about how the PFC combines motivation and the selection processes underlying cognitive control. We used functional magnetic resonance imaging in humans and found that the medial and lateral PFC have a parallel hierarchical organization from posterior to anterior regions for motivating and selecting behaviors, respectively. Moreover, using functional connectivity analyses, we found that functional interactions in this parallel system from medial to lateral PFC regions convey motivational incentives on the basis of rewards/penalties regulating the differential engagement of lateral PFC regions in top-down selection. Our results indicate that motivation is a dissociable function, reveal how the PFC integrates motivation and cognitive control in the service of decision-making, and have major implications for current theories of prefrontal executive function.