Nitrate therapy in stable angina pectoris.

Nitrate therapy in stable angina pectoris.
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稳定型心绞痛的硝酸盐治疗。

DOI:
10.1056/nejm198706253162606
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发表时间:
1987
期刊:
The New England journal of medicine
影响因子:
--
通讯作者:
J. Parker
J. Parker
中科院分区:
--
文献类型:
--
作者:
J. Parker

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硝化甘油于 1846 年首次合成,被称为 glonoine,最初被顺势疗法医生用于治疗头痛和心悸。1 Lauder Brunton 爵士于 1867 年报道了亚硝酸戊酯的使用,1879 年,William Murrell 描述了硝化甘油对心绞痛患者的有益作用。目前有多种不同配方的有机硝酸盐可供使用,但其临床疗效以及在持续治疗期间,硝酸盐的效果与其短期效果相比大幅减弱这一事实引起了争议。持续治疗期间抗心绞痛作用的减弱表明硝酸盐耐受。 。 。
NITROGLYCERIN, which was first synthesized in 1846 and known as glonoine, was initially employed by homeopathic physicians to treat headaches and palpitations.1 Sir Lauder Brunton2 reported on the use of amyl nitrite in 1867, and in 1879, William Murrell3 described the beneficial effects of nitroglycerin in patients with angina pectoris. Several organic nitrates with various formulations are currently available, but controversy has arisen regarding their clinical efficacy and the fact that during sustained therapy, the effects of the nitrates are substantially diminished as compared with their short-term effects. Attenuation of the antianginal effects during sustained therapy suggests that nitrate tolerance . . .
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发表时间: 1983
期刊: Circulation
影响因子: 37.8
作者:
Parker,JO;Fung,HL;Ruggirello,D;Stone,JA
通讯作者: Stone,JA
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影响因子: --
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影响因子: --
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