Parkinson's disease, pesticides and mitochondrial dysfunction
Parkinson's disease, pesticides and mitochondrial dysfunction
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DOI：
10.1016/s0166-2236(00)01789-6
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发表时间：
2001-05-01
影响因子：
15.9
通讯作者：
Jenner, P
中科院分区：
文献类型：
--
作者：
Jenner, P
选择性黑质变性与包含体形成引起的除草剂鱼藤酮的全身给药，通过抑制复合物I，提出了农药暴露和环境因素的问题，一般来说，作为帕金森病（PD）的原因。毒素诱导的复合物I抑制可能是PD的许多潜在原因之一，但它提醒我们注意环境中此类物质的危险，以及识别遗传易感人群的必要性。当脆弱的个体被发现时，也许他们应该远离花园。
Selective nigral degeneration with inclusion formation provoked by systemic administration of the herbicide rotenone, through inhibition of complex I, raises the question of pesticide exposure and environmental factors in general, as a cause of Parkinson's disease (PD). Toxin-induced complex I inhibition probably represents one of many potential causes of PD, but it alerts us to the dangers of such substances in the environment and the need to identify genetically susceptible populations. When vulnerable individuals become known, perhaps they should stay out of the garden.