The influence of age, sex and race on salivary kallikrein levels in human mixed saliva.
The influence of age, sex and race on salivary kallikrein levels in human mixed saliva.
复制标题
年龄、性别和种族对人类混合唾液中唾液激肽释放酶水平的影响。
DOI：
10.1007/bf01990947
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Lundblad,RL
中科院分区：
文献类型：
--
作者：
Jenzano,JW;Hogan,SL;Lundblad,RL
Variation in the level of salivary kallikrein in human saliva has been reported as a function of systemic conditions such as reduced salt intake and during the menstrual cycle. Higher levels of salivary kallikrein have been observed in subjects with tumors distant from the oral cavity when compared to control subjects. These studies have not evaluated factors, such as age, which might influence the concentration of glandular kallikrein in saliva. The purpose of the preseut study was to determine the variation of salivary kallikrein concentration as a function of age. Differences attributable to sex or race were also evaluated. Mixed saliva was collected from 114 subjects, ages 5–91, by paraffin stimulation. Samples were centrifuged and stored at −20°C for subsequent analysis. Glandular kallikrein activity was assayed usingd-ValylLeucylArginine-p-nitroanilide as the substrate. In a linear regression model which included sex, race, and age, levels only the factor of age had a significant effect on kallikrein levels. Thep-value for the reduced model including only the factor of age was 0.0406 and the R-square was 0.038. Further analysis revealed that females did exhibit significantly higher kallikrein in individuals 40 years or older and that the effect of age appeared to be limited to females. It is concluded that both gender and age must be considered when evaluating salivary kallikrein changes in relationship to systemic disease.
