The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus
The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus
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DOI：
10.1111/j.1464-5491.2004.01224.x
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发表时间：
2004-07-01
影响因子：
3.5
通讯作者：
Ruiz, J
中科院分区：
文献类型：
--
作者：
Lacquemant, C;Froguel, P;Ruiz, J
背景：位于染色体3q27上的ACRP30/脂联素基因编码丰富的脂肪细胞特异性分泌蛋白，该区域与代谢综合征相关。目的为探讨APM1基因单核苷酸多态(SNPs)与冠心病(CAD)易感性的关系，我们对高加索人2型糖尿病患者进行了病例对照研究。G与冠心病相关(OR1.9，95%CI1.2~2.9P=0.0036)。在多变量分析中，SNP+45T>；G仍然与冠心病相关(OR1.295%CI0.8-1.9P=0.017)，独立于包括代谢综合征组成部分在内的经典心血管危险因素。SNP单倍型分析揭示了所有SNP野生型等位基因的冠心病保护组合(OR0.5，95%CI0.3-0.7P=0.0006)。结论本研究在糖尿病患者中进行，揭示了APM1SNP+45个体与冠心病的关联。此外，SNP+45基因对冠心病的易感性与经典的心血管危险因素无关。需要进一步研究以确定SNP+45在CAD发展中的作用。然而，ACRP30/脂联素可能有助于高危人群(如2型糖尿病受试者)的动脉粥样硬化易感性。
Background The ACRP30/adiponectin gene on chromosome 3q27, a region linked to the metabolic syndrome, encodes for the abundant adipocyte-specific secreted protein. Consistent rodent and human studies suggested that this adipokine may be a molecular link between metabolic and cardiovascular diseases.Aims In order to investigate the role of single nucleotide polymorphisms (SNPs) within the APM1 gene in the susceptibility to coronary artery disease (CAD), we performed a case-control study on Caucasian Type 2 (non-insulin-dependent) diabetic patients, a population at high-risk for CAD.Methods Five APM1 SNPs were genotyped in 162 Type 2 diabetic French and Swiss subjects with CAD and in 315 Type 2 diabetic French and Swiss subjects without CAD.Results In univariate analysis, SNP+45 T>G was associated with CAD (OR 1.9 95% CI 1.2-2.9 P = 0.0036). In multivariate analysis, SNP+45 T>G remained associated with CAD (OR 1.2 95% CI 0.8-1.9 P = 0.017), independently of classical cardiovascular risk factors including components of the metabolic syndrome. SNP haplotype analyses revealed a CAD protective combination of all SNP wild-type alleles (OR 0.5 95% CI 0.3-0.7 P = 0.0006).Conclusions Our study, performed in diabetic subjects, revealed an association between individual SNP+45 in the APM1 gene and CAD. Furthermore, the susceptibility for CAD due to SNP+45 was independent of classic cardiovascular risk factors. Further studies will be necessary to confirm the role of SNP+45 in the development of CAD. However, ACRP30/adiponectin may contribute to atherosclerosis susceptibility in high-risk populations such as Type 2 diabetic subjects.