Growth factors and ovarian function: the IGF-I paradigm.
Growth factors and ovarian function: the IGF-I paradigm.
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生长因子和卵巢功能：IGF-I 范式。
DOI：
10.1159/000184144
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Adashi,EY
中科院分区：
文献类型：
--
作者：
Adashi,EY
大量的信息现在支持卵巢内IGF系统的存在，该系统充满了配体、受体和结合蛋白。卵巢内IGF系统最可能与促性腺激素激素作用的放大有关，其他潜在的调节作用目前仍在推测中。有充分的理由相信，在未来几年内，这一领域的工作将产生新的见解，以确定IGFs是否真的对卵巢功能不可或缺。此时，这一最终要求仍有待通过选择性切除卵巢IGF-I基因表达和检查这种操作对生殖潜力的影响来证明。
The large body of information now supports the existence of an intraovarian IGF system replete with ligands, receptors, and binding proteins. The intraovarian IGF system is most likely concerned with the amplification of gonadotropin hormonal action, other potential regulatory roles remaining speculative at this time. There is every reason to believe that work in this area in the upcoming several years will yield new insight necessary to establish whether or not IGFs are truly indispensable to ovarian function. At this time, this ultimate requirement remains to be demonstrated through selective ablation of ovarian IGF-I gene expression and the examination of the impact of such manipulation on reproductive potential.