Asymmetric cell division in B-subtilis involves a spiral-like intermediate of the cytokinetic protein FtsZ
Asymmetric cell division in B-subtilis involves a spiral-like intermediate of the cytokinetic protein FtsZ
复制标题
DOI：
10.1016/s0092-8674(02)00698-0
复制
发表时间：
2002-04-19
期刊：
影响因子：
64.5
通讯作者：
Losick, R
中科院分区：
文献类型：
--
作者：
Ben-Yehuda, S;Losick, R
芽孢杆菌枯草芽孢杆菌发育的一个基本特征是从中间分裂转变为不对称分裂。这种开关是由细胞动力学Z环的位置变化引起的，Z环由微管蛋白样蛋白FtsZ组成，在孢子形成期间从细胞中部到两极。我们报告说，内侧Z环被取代的螺旋状细丝FtsZ的生长沿着长轴的细胞。我们建议，灯丝介导的开关重新部署FtsZ的极点。螺旋的形成和极性Z环的开关主要是由孢子形成特异性的FtsZ基因转录增加和FtsZ相关蛋白SpollE基因的激活引起的。
A fundamental feature of development in the spore-forming bacterium Bacillus subtilis is the switch from medial to asymmetric division. The switch is brought about by a change in the location of the cytokinetic Z ring, which is composed of the tubulin-like protein FtsZ, from the cell middle to the poles during sporulation. We report that the medial Z ring is replaced by a spiral-like filament of FtsZ that grows along the long axis of the cell. We propose that the filament mediates the switch by redeploying FtsZ to the poles. Spiral formation and the switch to polar Z rings are largely caused by a sporulation-specific increase in transcription of the gene for FtsZ and activation of the gene for the FtsZ-assoclated protein SpollE.