Predictors of quality of life in people with Parkinson's disease: evidence for both domain specific and general relationships
Predictors of quality of life in people with Parkinson's disease: evidence for both domain specific and general relationships
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DOI：
10.3109/09638288.2014.883442
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发表时间：
2014-01-01
影响因子：
2.2
通讯作者：
Crawford, Trevor
中科院分区：
文献类型：
--
作者：
Simpson, Jane;Lekwuwa, Godwin;Crawford, Trevor
目的：评估帕金森病（PD）患者健康相关生活质量（HrQoL）的决定因素。方法：81例诊断为特发性PD的患者参加了一项基于横断面研究的研究。措施收集在社区环境中，包括既定的决定因素HrQoL（人口统计学，临床和认知变量），但也包括广泛的心理健康变量（抑郁，焦虑和压力），并首次积极的心理功能（乐观和自尊）。HrQoL通过完整版帕金森病问卷（PDQ-39）进行测量，其中包括8个功能领域。结果如下：心理健康措施（抑郁，焦虑和压力）比任何其他块的决定因素更有影响力，并影响了更广泛的HrQoL领域，包括物理的。有一些特定领域关系的证据，例如。G.身体决定因素和更注重身体的HrQoL领域之间，以及心理健康决定因素和情感幸福之间。然而，认知能力并不影响认知障碍的HrQoL域。结论：考虑到影响HrQoL的许多变量，多学科方法的贡献至关重要;特别是，如果仅提供身体康复，则不太可能显著改善HrQoL。康复可能是有益的HrQoL方面只有当它是计划和交付整体。
Purpose: To assess the determinants of health-related quality of life (HrQoL) in people with Parkinson's disease (PD). Method: Eighty-one people with a diagnosis of idiopathic PD took part in a cross-sectional questionnaire-based study. Measures were collected in a community setting and included established determinants of HrQoL (demographic, clinical and cognitive variables) but also included a wide range of mental health variables (depression, anxiety and stress) and, for the first time, positive psychological functioning (optimism and self-esteem). HrQoL was measured by the full version of the Parkinson's Disease Questionnaire (PDQ-39) which includes eight domains of functioning. Results: Mental health measures (depression, anxiety and stress) were more influential than any other block of determinants and influenced a broader array of HrQoL domains including physical ones. There was some evidence of domain-specific relationships, e. g. between physical determinants and the more physically-oriented HrQoL domains, and between mental health determinants and emotional well-being. However, cognitive ability did not influence the HrQoL domain of cognitive impairment. Conclusions: The contribution of a multi-disciplinary approach is crucial given the many variables which affect HrQoL; in particular, significant overall improvements on HrQoL are unlikely if only physical rehabilitation is offered. Rehabilitation is likely to be beneficial in terms of HrQoL only if it is planned and delivered holistically.