Contrast-enhanced magnetic resonance imaging of central nervous system tumors: agents, mechanisms, and applications.
Contrast-enhanced magnetic resonance imaging of central nervous system tumors: agents, mechanisms, and applications.
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DOI：
10.1097/01.rmr.0000245464.36148.dc
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发表时间：
2006-04-01
期刊：
影响因子：
--
通讯作者：
Giesel, Frederik L
中科院分区：
文献类型：
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作者：
Essig, Marco;Weber, Marc-Andre;Giesel, Frederik L
脑肿瘤是年轻人中最常见的肿瘤之一，与高死亡率和致残率有关。磁共振成像（MRI）被广泛认为是评估脑肿瘤最敏感的成像方式。由于脑肿瘤的检测、表征和精确描绘需要高的病变对比，这取决于病变与周围组织的信号，因此常规给予造影剂。解剖和功能、造影剂为基础的MRI技术允许更好的鉴别诊断、分级，特别是治疗决策、计划和随访。本文将对脑肿瘤造影增强的基本原理进行综述。血脑屏障被破坏的潜在病理和药物的影响将被讨论。本文将概述目前可用的造影剂，以及剂量、场强和应用对肿瘤组织造影剂的影响。具有挑战性的，对比增强的，功能性成像技术，如灌注MRI和动态对比增强MRI，从技术方面和临床经验两方面介绍了脑肿瘤的评估。与传统的解剖MRI技术相比，我们将讨论其优点，以及可能存在的缺陷和缺点。
Brain tumors are one of the most common neoplasms in young adults and are associated with a high mortality and disability rate. Magnetic resonance imaging (MRI) is widely accepted to be the most sensitive imaging modality in the assessment of cerebral neoplasms. Because the detection, characterization, and exact delineation of brain tumors require a high lesion contrast that depends on the signal of the lesion in relation to the surrounding tissue, contrast media is given routinely. Anatomical and functional, contrast agent-based MRI techniques allow for a better differential diagnosis, grading, and especially therapy decision, planing, and follow-up. In this article, the basics of contrast enhancement of brain tumors will be reviewed. The underlying pathology of a disrupted blood-brain barrier and drug influences will be discussed. An overview of the currently available contrast media and the influences of dosage, field strength, and application on the tumor tissue contrast will be given. Challenging, contrast-enhanced, functional imaging techniques, such as perfusion MRI and dynamic contrast-enhanced MRI, are presented both from the technical side and the clinical experience in the assessment of brain tumors. The advantages over conventional, anatomical MRI techniques will be discussed as well as possible pitfalls and drawbacks.