EFFECT OF GASTRIC-ACID ON THE PATHOGENESIS OF SUBGLOTTIC STENOSIS
EFFECT OF GASTRIC-ACID ON THE PATHOGENESIS OF SUBGLOTTIC STENOSIS
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DOI：
10.1177/000348948509400521
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发表时间：
1985-01-01
影响因子：
1.4
通讯作者：
MARSHALL, RB
中科院分区：
文献类型：
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作者：
LITTLE, FB;KOHUT, RI;MARSHALL, RB
1例声门下狭窄，常规治疗无效，与无症状胃酸吸入喉有关。一旦通过使用抗酸剂和H2受体阻滞剂控制反流，声门下狭窄消退，患者可以拔管。这个病例导致使用声门下狭窄的实验犬模型来检查胃酸作为声门下狭窄发展的致病因素。在对照组动物中，粘膜病变愈合，没有狭窄的发展。在实验动物的粘膜病变涂上胃酸，声门下狭窄的发展。当软骨膜和软骨受到侵犯并施加胃酸时，狭窄甚至更严重，发展更快。
A case of subglottic stenosis, recalcitrant to conventional therapy, was associated with asymptomatic aspiration of gastric acid into the larynx. Once the reflux was controlled by use of an antacid regimen and an H2blocker, the subglottic stenosis resolved and the patient could be decannulated. This case led to the use of an experimental canine model of subglottic stenosis to examine gastric acid as a pathogenic factor in the development of subglottic stenosis. In control animals, mucosal lesions healed without development of stenosis. In experimental animals with mucosal lesions painted with gastric acid, subglottic stenosis developed. When perichondrium and cartilage were violated and gastric acid applied, stenosis was even more severe and developed more rapidly.