Variations in Connectivity in the Sensorimotor and Default-Mode Networks During the First Nocturnal Sleep Cycle
Variations in Connectivity in the Sensorimotor and Default-Mode Networks During the First Nocturnal Sleep Cycle
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DOI：
10.1089/brain.2012.0075
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发表时间：
2012-09
影响因子：
3.4
通讯作者：
Changwei W. Wu;Po-Yu Liu;Pei-Jung Tsai;Yu-Chin Wu;Ching-Sui Hung;Yu-Che Tsai;Kuan-Hung Cho;B. B
中科院分区：
文献类型：
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作者：
Changwei W. Wu;Po-Yu Liu;Pei-Jung Tsai;Yu-Chin Wu;Ching-Sui Hung;Yu-Che Tsai;Kuan-Hung Cho;B. B
使用同步脑电图（EEG）和功能性磁共振成像记录来研究人类的睡眠功能，以提供具有空间精度的准确睡眠评分。最近的研究表明，自发脑振荡和功能连接在非快速眼动（NREM）睡眠期间分离;这导致自发的认知过程，如记忆巩固和情绪调节。然而，在睡眠阶段或睡眠/唤醒转换之间的网络连接的变化需要进一步阐明。我们观察了18名健康参与者的感觉运动和默认模式网络（DMN）的连接变化，这些网络由午夜睡眠介导。结果表明：（1）随着NREM睡眠的加深，两个网络的功能连接都表现出越来越多的分离，而超连接则发生在快速眼动（REM）睡眠期间;（2）与睡眠前的连接相比，DMN在觉醒后立即呈现出可比较的连接模式，而感觉运动网络的连接仍然中断。这些发现表明，在NREM和REM睡眠期间，连接模式分别在两个皮层网络中分离和重新连接。在人醒来后，DMN连接在感觉运动重新连接之前重新建立。这些与睡眠相关的动态分离和睡眠/觉醒条件之间的重新连接可能为理解睡眠中的认知调节提供了关键。如果是这样的话，连通性的变化可能会成为脑电图信号之外的另一种指标，以揭示睡眠期间发生的自发过程。
The function of sleep in humans has been investigated using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging recordings to provide accurate sleep scores with spatial precision. Recent studies have demonstrated that spontaneous brain oscillations and functional connectivity dissociate during nonrapid eye movement (NREM) sleep; this leads to spontaneous cognitive processes, such as memory consolidation and emotional modulation. However, variations in network connectivity across the sleep stages or between sleep/wake transitions require further elucidation. We observed changes in the connectivity of the sensorimotor and default-mode networks (DMN) mediated by midnight sleep among 18 healthy participants. The results indicated that (1) functional connectivity in both networks showed increasing dissociation as NREM sleep deepened, whereas hyperconnectivity occurred during rapid eye movement (REM) sleep; and (2) compared with connectivity before sleep, the DMN presented a comparable connectivity pattern immediately after awakening, whereas the connectivity of the sensorimotor network remained disrupted. These findings showed that connectivity patterns dissociate and reconnect coherently in both cortical networks during NREM and REM sleep, respectively. After the person awakened, the DMN connectivity was re-established before the sensorimotor reconnection. These dynamic sleep-related dissociations and reconnections between sleep/wake conditions might provide the key to understanding cognitive modulations in sleep. If so, connectivity changes might serve as an alternative indicator beyond the EEG signature to unveil the spontaneous processes that occur during sleep.