MITOCHONDRIAL DECAY IN AGING
MITOCHONDRIAL DECAY IN AGING
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DOI：
10.1016/0925-4439(95)00024-x
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发表时间：
1995-05-24
影响因子：
6.2
通讯作者：
HAGEN, TM
中科院分区：
文献类型：
--
作者：
AMES, BN;SHIGENAGA, MK;HAGEN, TM
随着年龄的增长，一些线粒体功能下降。影响因素包括质子穿过线粒体内膜的固有泄漏速率（与氧化剂形成相关）、膜流动性降低以及心磷脂的水平和功能降低，心磷脂支持线粒体内膜的许多蛋白质的功能。线粒体产生的氧化剂似乎是随着年龄增长而积累的氧化损伤的主要来源。有证据支持这样的建议，即由于氧化损伤导致的与年龄相关的线粒体缺陷的积累可能是细胞、组织和生物体衰老的主要原因。
Several mitochondrial functions decline with age. The contributing factors include, the intrinsic rate of proton leakage across the inner mitochondrial membrane (a correlate of oxidant formation), decreased membrane fluidity, and decreased levels and function of cardiolipin, which supports the function of many of the proteins of the inner mitochondrial membrane. Oxidants generated by mitochondria appear to be the major source of the oxidative lesions that accumulate with age. Evidence supports the suggestion that age-associated accumulation of mitochondrial deficits due to oxidative damage is likely to be a major contributor to cellular, tissue, and organismal aging.