Cell-Based Strategies for Meniscus Tissue Engineering.
Cell-Based Strategies for Meniscus Tissue Engineering.
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DOI：
10.1155/2016/4717184
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发表时间：
2016
影响因子：
4.3
通讯作者：
Guo Q
中科院分区：
文献类型：
--
作者：
Niu W;Guo W;Han S;Zhu Y;Liu S;Guo Q
半月板损伤仍然是一个重大的挑战，由于愈合潜力差的内无血管区。经过一系列的研究和临床试验，组织工程被认为是半月板修复和再生的一个很有前途的前景。作为组织工程的关键因素之一，细胞被认为是非常有益的，在产生仿生半月板结构，以取代病人受伤的。因此，以细胞为基础的半月板组织工程策略在半月板再生中起着基础性作用。目前半月板组织工程的细胞培养策略主要是单细胞型策略，细胞共培养策略也被应用于半月板组织工程。同样，一方面，基于模拟神经元不同细胞和内部结构的区域重演策略也受到了广泛的关注。另一方面，没有任何支架的细胞自组装策略可能是构建仿生半月板的更好方法。本文就半月板组织工程的细胞种子及其应用策略作一综述。我们还讨论了半月板修复实验的最新进展和成就，进一步提高了我们对半月板组织工程的理解。
Meniscus injuries remain a significant challenge due to the poor healing potential of the inner avascular zone. Following a series of studies and clinical trials, tissue engineering is considered a promising prospect for meniscus repair and regeneration. As one of the key factors in tissue engineering, cells are believed to be highly beneficial in generating bionic meniscus structures to replace injured ones in patients. Therefore, cell-based strategies for meniscus tissue engineering play a fundamental role in meniscal regeneration. According to current studies, the main cell-based strategies for meniscus tissue engineering are single cell type strategies; cell coculture strategies also were applied to meniscus tissue engineering. Likewise, on the one side, the zonal recapitulation strategies based on mimicking meniscal differing cells and internal architectures have received wide attentions. On the other side, cell self-assembling strategies without any scaffolds may be a better way to build a bionic meniscus. In this review, we primarily discuss cell seeds for meniscus tissue engineering and their application strategies. We also discuss recent advances and achievements in meniscus repair experiments that further improve our understanding of meniscus tissue engineering.