Study of individual erythrocyte deformability susceptibility to INFeD and ethanol using a microfluidic chip.
Study of individual erythrocyte deformability susceptibility to INFeD and ethanol using a microfluidic chip.
复制标题
使用微流控芯片研究个体红细胞变形对 INFeD 和乙醇的敏感性
DOI：
10.1038/srep22929
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发表时间：
2016-03-11
影响因子：
4.6
通讯作者：
Han J
中科院分区：
文献类型：
--
作者：
Liu L;Huang S;Xu X;Han J
Human red blood cells (RBCs) deformability in vitro was assessed during iron dextran (INFeD) loading and/or ethanol co-administration using microfluidic deformability screening. The results showed donor-specific variations in dose dependent deformability shift were revealed below 500 μg/mL iron dextran. Two out of nine blood samples exhibited significant cell stiffening at 500 μg/mL iron dextran loading concentration (p < 0.05, Tukey test). More interestingly, co-administration of moderate amount of ethanol was identified to have significant protective effects on RBC deformability. We also noted that ethanol can reverse the deformability of impaired RBCs. Meanwhile obvious donor dependent response to ethanol administration on RBC deformability was noted using our biomimetic microfluidic chip.
