Dietary fiber, source foods and colorectal cancer risk: the Fukuoka Colorectal Cancer Study
Dietary fiber, source foods and colorectal cancer risk: the Fukuoka Colorectal Cancer Study
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DOI：
10.3109/00365521.2010.492528
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发表时间：
2010-10-01
影响因子：
1.9
通讯作者：
Terasaka, Reiji
中科院分区：
文献类型：
--
作者：
Uchida, Kazuhiro;Kono, Suminori;Terasaka, Reiji
Objective.尽管实验室工作提供了大量证据，但关于膳食纤维在结直肠癌发生中的作用的流行病学证据仍然难以捉摸。我们在福冈结直肠癌研究中调查了膳食纤维和来源食物与结直肠癌风险的关系，这是一项基于社区的病例对照研究。材料和方法。研究对象为816例结直肠癌患者和815例社区对照。营养素和食物摄入量估计的基础上，对148个饮食项目的计算机辅助采访。根据膳食纤维和食物组的能量调整摄入量的五分位数类别，通过调整非膳食因素和钙和n-3脂肪酸的膳食摄入量，获得结直肠癌的比值比。结果总膳食纤维、可溶性膳食纤维和不可溶性膳食纤维与结直肠癌的总体风险或特定津贴风险没有可测量的相关性。相比之下，大米消费与结直肠癌风险降低相关（趋势p = 0.03），特别是远端结肠癌和直肠癌（趋势p = 0.02），而非大米谷物的高摄入量往往与结肠癌风险增加相关（趋势p = 0.07）。蔬菜摄入量与结直肠癌之间没有关联，而水果摄入量最低的人患结直肠癌的风险往往会增加。结论.目前的研究没有证实膳食纤维和结直肠癌之间的保护性联系，但表明与大米消费相关的远端结直肠癌风险降低。
Objective. Despite much evidence from laboratory work, epidemiological evidence remains elusive regarding the role of dietary fiber in colorectal carcinogenesis. We investigated associations of dietary fiber and source foods with colorectal cancer risk in the Fukuoka Colorectal Cancer Study, a community-based case-control study. Material and methods. The study subjects were 816 incident cases of colorectal cancer and 815 community controls. Nutrient and food intakes were estimated on the basis of a computer-assisted interview regarding 148 dietary items. Odds ratios of colorectal cancer according to quintile categories of energy-adjusted intakes of dietary fiber and food groups were obtained with adjustment for non-dietary factors and dietary intakes of calcium and n-3 fatty acids. Results. Total, soluble and insoluble dietary fibers were not measurably associated with overall risk or subsite-specific risk of colorectal cancer. By contrast, rice consumption was associated with a decreased risk of colorectal cancer (trend p = 0.03), particularly of distal colon and rectal cancer (trend p = 0.02), and high intake of non-rice cereals tended to be related to an increased risk of colon cancer (trend p = 0.07). There was no association between vegetable consumption and colorectal cancer, whereas individuals with the lowest intake of fruits tended to have an increased risk of colorectal cancer. Conclusions. The present study did not corroborate a protective association between dietary fiber and colorectal cancer, but suggested a decreased risk of distal colorectal cancer associated with rice consumption.