Antimycobacterial polyynes of Devil's Club (Oplopanax horridus), a North American native medicinal plant
Antimycobacterial polyynes of Devil's Club (Oplopanax horridus), a North American native medicinal plant
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DOI：
10.1021/np970182j
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发表时间：
1997-11-01
影响因子：
5.1
通讯作者：
Stokes, RW
中科院分区：
文献类型：
--
作者：
Kobaisy, M;Abramowski, Z;Stokes, RW
两种新的（3 和 5）以及三种已知的（1,2 和 4）多炔是从北美药用植物魔鬼俱乐部（Olopopanax horridus；五加科）中分离出来的。通过 H-1 和 C-13 NMR 确定结构。 2和5的绝对构型通过应用Mosher方法确定。所有多炔都表现出显着的抗念珠菌、抗菌和抗分枝杆菌活性，在纸片扩散测定中能够以 10 μg/纸片杀死结核分枝杆菌和耐异烟肼的鸟分枝杆菌。
Two new (3 and 5), as well as three known (1,2, and 4), polyynes were isolated from Devil's Club (Oplopanax horridus; Araliaceae): a medicinal plant of North America. The structures were established by H-1 and C-13 NMR. The absolute configurations of 2 and 5 were determined by application of Mosher's method. All the polyynes exhibited significant anti-Candida, antibacterial, and antimycobacterial activity, with an ability to kill Mycobacterium tuberculosis and isoniazid-resistant Mycobacterium avium at 10 mu g/disk in a disk diffusion assay.