Toll-like receptors as potential therapeutic targets for multiple diseases
Toll-like receptors as potential therapeutic targets for multiple diseases
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DOI：
10.1038/nrd914
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发表时间：
2002-10
影响因子：
120.1
通讯作者：
C. Zuany‐Amorim;J. Hastewell;C. Walker
中科院分区：
文献类型：
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作者：
C. Zuany‐Amorim;J. Hastewell;C. Walker
Toll样受体（TLR）家族通过其识别病原体相关分子模式的能力作为免疫应答的潜在调节剂和控制剂而受到相当大的关注。内源性配体以及微生物组分被TLR识别的发现，以及小分子量合成化合物激活TLR的发现，引起了人们对这些受体作为开发多种疾病新疗法的潜在靶点的兴趣。在这篇综述中，我们讨论了TLR激动剂或拮抗剂在慢性炎症性疾病中的当前和未来应用，并强调了与此类方法相关的潜在问题。
The family of Toll-like receptors (TLRs) is receiving considerable attention as potential regulators and controllers of the immune response through their ability to recognize pathogen-associated molecular patterns. The discovery that endogenous ligands, as well as microbial components, are recognized by TLRs, and that small-molecular-mass synthetic compounds activate TLRs, raised interest in these receptors as potential targets for the development of new therapies for multiple diseases. In this review, we discuss the current and future use of TLR agonists or antagonists in chronic inflammatory diseases and highlight potential problems that are associated with such approaches.