Tumor-induced anorexia in the Wistar rat.
Tumor-induced anorexia in the Wistar rat.
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Wistar 大鼠肿瘤诱发的厌食症。
DOI：
10.1126/science.6941477
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Rossini,AA
中科院分区：
文献类型：
--
作者：
Mordes,JP;Rossini,AA
Wistar大鼠可移植间质细胞肿瘤LTW(m)在移植后2周内引起宿主食量减少和体重减轻。肿瘤很小，没有转移，也没有影响生化功能的几个参数。当肿瘤被切除后，食物摄入量和体重在72小时内出现增加，并持续下去。肿瘤再植导致厌食症复发。其中一方有肿瘤的异种配对大鼠也经历了体重减轻。与荷瘤大鼠异种共生的大鼠比与对照大鼠异种共生的大鼠体重增加少。这些观察结果表明，LTW(m)肿瘤引起厌食症，而这种厌食症是由循环物质介导的。
The transplantable Leydig cell tumor of Wistar rats, LTW(m), caused decreased food consumption and weight loss in the host within 2 weeks of implantation. The tumor was small, did not metastasize, and did not affect several parameters of biochemical function. When the tumors were removed, increases in food intake and body weight occurred within 72 hours and were sustained. Reimplantation of tumors caused anorexia to recur. Parabiotic pairs of rats with tumor in one partner also experienced weight loss. Those rats in parabiosis with tumor-bearing rats gained less weight than those in parabiosis with control rats. These observations suggest that the LTW(m) tumor causes anorexia and that this anorexia is mediated by a circulating substance.