Surgical treatment of intraventricular tumors associated with tuberous sclerosis
Surgical treatment of intraventricular tumors associated with tuberous sclerosis
复制标题
结节性硬化症相关脑室内肿瘤的手术治疗
DOI：
10.1007/bf00301665
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
S. Jóźwiak
中科院分区：
文献类型：
--
作者：
M. Roszkowski;K. Drabik;S. Barszcz;S. Jóźwiak
1987-1992年，在儿童健康中心儿科神经外科治疗了6例与结节性硬化症（TS）相关的脑室内肿瘤患儿。患者年龄7 ~ 15岁。根据Gomez诊断标准诊断TS。计算机断层扫描（CT）和磁共振成像显示脑室内肿瘤伴脑室扩大和多发室管膜下结节，常见于TS病例。所有肿瘤均经额叶皮质入路全切除，术后恢复良好。一位病人，两个平行的肿瘤在两个额骨角，进行了一期手术，成功地全部切除。病理组织学检查均为室管膜下巨细胞星形细胞瘤。与TS相关的SGCA的生长模式，连续CT扫描记录了几年，描述。讨论了肿瘤的诊断和手术治疗，并建议TS患者至少每2年定期进行CT扫描。
Six children with intraventricular tumors associated with tuberous sclerosis (TS) were treated at the Children's Health Center, Department of Pediatric Neurosurgery, in the period 1987–1992. The age of the patients ranged from 7 to 15 years. TS was diagnosed according to Gomez diagnostic criteria. Computer tomography (CT) and magnetic resonance imaging showed intraventricular tumors associated with ventricular enlargement and multiple subependymal nodules commonly observed in cases of TS. All tumors were removed totally through frontal transcortical approach, with uneventful postoperative recovery. One patient, with two parallel tumors in the two frontal horns, underwent one-stage surgery with successful total removal. Histopathological examination in all cases showed subependymal giant cell astrocytoma (SGCA). The growth pattern of SGCA associated with TS, documented by sequential CT scans over several years, is described. The diagnosis and surgical treatment of the tumor are discussed, and periodic CT scanning, at least every 2 years, is recommended for patients with TS.