NUCLEOTIDE-SEQUENCE OF LAC OPERATOR
NUCLEOTIDE-SEQUENCE OF LAC OPERATOR
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DOI：
10.1073/pnas.70.12.3581
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发表时间：
1973-01-01
影响因子：
11.1
通讯作者：
MAXAM, A
中科院分区：
文献类型：
--
作者：
GILBERT, W;MAXAM, A
阻遏蛋白保护转录因子不被脱氧核糖核酸酶消化。受保护的片段是双链的，长约27个碱基对。我们确定了该片段的RNA转录拷贝序列，并给出了24个碱基对的序列。它是：5′--T G G A A T G T G A G C G G A T A A C A T 3′--A C C T T A C A C T C G C C T A T G T A A A 5′该序列具有2重对称区域;最长的两个区域被DNA双螺旋的一个转角分开。
Thelacrepressor protects thelacoperator against digestion with deoxyribonuclease. The protected fragment is double-stranded and about 27 base-pairs long. We determined the sequence of RNA transcription copies of this fragment and present a sequence for 24 base pairs. It is: 5′--T G G A A T T G T G A G C G G A T A A C A A T T 3′ 3′--A C C T T A A C A C T C G C C T A T T G T T A A 5′ The sequence has 2-fold symmetry regions; the two longest are separated by one turn of the DNA double helix.