A novel noninvasive measurement technique for analyzing the pressure pulse waveform of the radial artery
A novel noninvasive measurement technique for analyzing the pressure pulse waveform of the radial artery
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DOI：
10.1109/tbme.2007.910681
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发表时间：
2008-01-01
影响因子：
4.6
通讯作者：
Liang, Wen-Miin
中科院分区：
文献类型：
--
作者：
Tyan, Chu-Chang;Liu, Shing-Hong;Liang, Wen-Miin
以往对桡动脉脉搏波形的无创测量未采用标准定位程序。在此，我们提出一种新的无创测量仪器，它具有双轴机制，并采用标准定位程序来检测准确测量压力脉搏波形（PPW）的最佳位置。设计了一种改进的传感器，可同时测量动脉直径变化波形（ADCW）和PPW。将动脉视为圆柱体，如果传感器不在动脉宽度的中间，测量的波形就会失真。此外，血管是有弹性的，其顺应性随跨壁压而变化，当跨壁压为零时最大。传感器应检测失真尽可能小的PPW，因此，通过对血管几何形状的分析和动脉模型，基于ADCW为X轴和Z轴设计了一种标准定位程序。为了验证X轴扫描程序的分辨率，采用回声法测量了10名健康受试者的桡动脉外径。扫描宽度与实际动脉直径之间的差异为0.36±0.23毫米（平均值±标准差）。最后，在最佳位置测量的PPW被用于诊断60名以胸痛为主要症状的老年受试者的心肌缺血症状，并以运动心电图作为参考，对有心肌缺血和无心肌缺血的个体进行比较。PPW分析使用了频域中的谐波成分。我们发现傅里叶级数的四次谐波在两组之间有显著差异（p = 0.0039），这与先前的研究一致。结果表明我们的无创测量仪器非常适合分析桡动脉的PPW。
Previous noninvasive measurements of the pulse waveform of the radial artery have not employed standard positioning procedures. Here, we propose a new noninvasive measuring apparatus that has a two-axis mechanism and employs a standard positioning procedure for detecting the optimal site for accurately measuring the pressure pulse waveform (PPW). A modified sensor was designed to simultaneously measure the arterial diameter changed waveform (ADCW) and PPW. Considering the artery as a cylinder, the measured waveform would be distorted if the sensor were not at the middle of arterial width. Moreover, a blood vessel is elastic, and its compliance changes with the transmural pressure, being maximal when the transmural pressure is equal to zero. The sensor should detect the PPW with the lowest possible distortion and, hence, an analysis of the vascular geometry and an arterial model were used to design a standard positioning procedure based on the ADCW for the X and Z axes. In order to verify the resolution of the X axis scanning procedure, the echo method was used to measure the radial artery outer diameter in ten healthy subjects. The difference between the scanning width and the actual arterial diameter was 0.36 +/- 0.23 min (mean +/- SD). Finally, the PPW as measured at the optimal position was used to diagnose myocardial ischemia symptoms in 60 elderly subjects whose chief complaint was chest pain, with the exercise electrocardiogram being used as a reference to compare between individuals with and without myocardial ischemia. The PPW analysis used the harmonic components in the frequency domain. We found that the fourth harmonic of the Fourier series differed significantly between the groups (p = 0.0039), which is consistent with previous studies. The results indicate that our noninvasive measurement apparatus is very suitable for analyzing the PPW of the radial artery.