CELL-DIVISION, DIFFERENTIATION AND DYNAMIC CLUSTERING
CELL-DIVISION, DIFFERENTIATION AND DYNAMIC CLUSTERING
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DOI：
10.1016/0167-2789(94)90277-1
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发表时间：
1994-08-01
期刊：
影响因子：
4
通讯作者：
YOMO, T
中科院分区：
文献类型：
--
作者：
KANEKO, K;YOMO, T
提出了一种基于全局耦合非线性系统动态聚类的细胞分化机制。一个简单的模型与代谢反应，积极运输的化学品从媒体，和细胞分裂被发现显示三个连续的阶段与细胞数量的增长;连贯的增长，动态集群，和固定的细胞分化。在最后一个阶段，差异的活动，生殖线分离，体细胞分化，和homeochaos稳定性对外部扰动found. Our的结果，提供了一个简单的解释的实验前面的文件，意味着细胞分化可以发生没有空间模式。从动力系统的观点出发，提出了“开放混沌”的新概念，作为一种新的和普遍的情况下，系统的元素越来越多，也看到在经济学和社会学。
A novel mechanism for cell differentiation is proposed, based on the dynamic clustering in a globally coupled nonlinear system. A simple model with metabolic reaction, active transport of chemicals from media, and cell division is found to show three successive stages with the growth of the number of cells; coherent growth, dynamic clustering, and fixed cell differentiation. At the last stage, disparity in activities, germ line segregation, somatic cell differentiation, and homeochaotic stability against external perturbation are found. Our results, providing a simple interpretation of the experiments of the preceding paper, imply that cell differentiation can occur without a spatial pattern. From dynamical systems viewpoint, the new concept of ''open chaos'' is proposed, as a novel and general scenario for systems with growing numbers of elements, also seen in economics and sociology.