Sortilin: a new player in dementia and Alzheimer-type neuropathology
Sortilin: a new player in dementia and Alzheimer-type neuropathology
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Sortilin：痴呆和阿尔茨海默型神经病理学的新参与者
DOI：
10.1139/bcb-2018-0023
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发表时间：
2018
影响因子：
2.9
通讯作者：
Yan Xiao Xin
中科院分区：
文献类型：
--
作者：
Xu Shu Yin;Jiang Juan;Pan Aihua;Yan Cai;Yan Xiao Xin
阿尔茨海默病相关的痴呆症现在是世界上大多数人群中的主要死亡因素，其中阿尔茨海默病（AD）是导致痴呆症的主要神经退行性疾病。痴呆症，特别是AD的致病机制在很大程度上仍然未知。迄今为止，开发针对该疾病标志性病变（如淀粉样斑块和缠结病变）的药物的努力尚未成功。液泡蛋白分选10 p（Vps10 p）家族在细胞膜信号转导、蛋白分选和胞内区室之间的运输中起关键作用。在过去的几年中出现的数据点参与这个家庭在AD的发展。具体而言，Vps10p成员分拣蛋白已被证明参与淀粉样斑块形成、tau磷酸化、异常蛋白分选和凋亡。在这篇小综述中，我们更新了动物实验和人脑研究的一些最新发现，表明异常分拣蛋白表达与AD型神经病理学相关，从而进一步研究可能导致AD治疗发展的新靶点。
Age-related dementias are now a major mortality factor among most human populations in the world, with Alzheimer’s disease (AD) being the leading dementia-causing neurodegenerative disease. The pathogenic mechanism underlying dementia disorders, and AD in particular, remained largely unknown. Efforts to develop drugs targeting the disease’s hallmark lesions, such as amyloid plaque and tangle pathologies, have been unsuccessful so far. The vacuolar protein sorting 10p (Vps10p) family plays a critical role in membrane signal transduction and protein sorting and trafficking between intracellular compartments. Data emerging during the past few years point to an involvement of this family in the development of AD. Specifically, the Vps10p member sortilin has been shown to participate in amyloid plaque formation, tau phosphorylation, abnormal protein sorting and apoptosis. In this minireview, we update some latest findings from animal experiments and human brain studies suggesting that abnormal sortilin expression is associated with AD-type neuropathology, warranting further research that might lead to novel targets for the development of AD therapies.