Red blood cells, transfusion-related acute lung injury, and lipids: a role for liporeduction?
Red blood cells, transfusion-related acute lung injury, and lipids: a role for liporeduction?
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红细胞、输血相关的急性肺损伤和脂质：减脂的作用？
DOI：
10.1111/j.1537-2995.2011.03307.x
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发表时间：
2011
期刊：
影响因子：
2.9
通讯作者：
Klein,HarveyG
中科院分区：
文献类型：
--
作者：
Stroncek,DavidF;Klein,HarveyG
自从输血相关急性肺损伤 (TRALI) 成为输血相关死亡的主要原因以来，人们付出了大量努力来更好地了解 TRALI 的病理生理学并降低其发病率。已发现许多供体和产品因素与输注血小板和血浆成分相关的 TRALI 发病机制有关，但由于输注红细胞成分而导致的 TRALI 更难以解释，因为在添加剂/防腐剂溶液中制备的红细胞成分含有很少的血浆。与红细胞成分输注相关的 TRALI 尤为重要，因为大量红细胞输注导致 TRALI 病例的绝对数量接近血浆和血小板输注所见的总数。 Silliman 等人在本期《输血》中的手稿描述了红细胞储存过程中积累的新因子，这可能有助于解释红细胞输注如何引起 TRALI。 1TRALI 在输注浓缩血小板和血浆制品后发生的可能性远高于输注红细胞成分后发生的可能性。 2, 3 这可能是由于与储存在添加剂/防腐剂溶液中的红细胞成分相比，血小板和血浆成分中的血浆量存在显着差异。许多研究表明，输注血浆中含有的血小板和血浆成分中的白细胞抗体是TRALI的重要原因。病例对照研究证实，输注大量血浆或含血浆的血液成分的受者更容易发生 TRALI。 4 此外，输注经产妇的血浆和血小板比输注其他捐献者的血浆更容易引起 TRALI，这表明同种免疫是 TRALI 发病机制的一个重要因素。 3, 5 其他病例对照研究发现，输注带有针对 HLA II 类和中性粒细胞特异性抗原的抗体的捐赠者的血小板和血浆成分更有可能发生 TRALI。 5 此外，最近的一项多中心回顾性队列研究发现，HLA 抗体供体成分受者的 TRALI 发生率高于对照成分受者，但差异未达到统计学显着性。 6
Since transfusion-related acute lung injury (TRALI) emerged as the leading cause of transfusion associated mortality, considerable effort has been spent to better understand the pathophysiology of TRALI and reduce its incidence. Many donor and product factors have been found to be involved with the pathogenesis of TRALI associated with the transfusion of platelet and plasma components, but TRALI due to the transfusion of RBC components has been more difficult to explain since RBC components prepared in additive/preservative solutions contain very little plasma. TRALI associated with RBC component transfusions is especially important because the large number of RBC transfusions result in an absolute number of TRALI cases approaching the total seen with plasma and platelet transfusions. The manuscript by Silliman et al in this issue of Transfusion, describes novel factors that accumulate during RBC storage which may help to explain how TRALI is caused by RBC transfusion. 1TRALI is far more likely to occur following the transfusion of platelet concentrates and plasma products than RBC components. 2, 3 This is likely due to the marked difference in the quantity of plasma in platelet and plasma components compared to RBC components stored in additive/preservative solutions. Many studies have shown that the transfusion of leukocyte antibodies in the plasma contained in the platelet and plasma components are an important cause of TRALI. Case-control studies have confirmed that TRALI is more likely to occur in recipients transfused with greater quantities of plasma or plasma-containing blood components. 4 In addition, the transfusion of plasma and platelets from multiparous women is more likely to cause TRALI than is plasma from other donors, implying that alloimmunization is an important factor in the pathogenesis of TRALI. 3, 5 Other case-control studies have found that the transfusion of platelet and plasma components from donors with antibodies directed to HLA Class II and neutrophil-specific antigens are more likely to develop TRALI. 5 In addition, a recent multicenter retrospective cohort study has found a higher incidence of TRALI in recipients of components from donors with HLA antibodies than in recipients of control components, but the difference did not reach statistical significance. 6
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影响因子：
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作者：
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DOI：
10.1177/31.9.6350438
发表时间：
1983
期刊：
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
影响因子：
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作者：
Silverman,AJ;Hou-Yu,A;Oldfield,BJ
通讯作者：
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