Cadherin junctions and their cytoskeleton(s)
Cadherin junctions and their cytoskeleton(s)
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DOI：
10.1016/j.ceb.2012.10.010
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发表时间：
2013-02-01
影响因子：
7.5
通讯作者：
Yap, Alpha S.
中科院分区：
文献类型：
--
作者：
Brieher, William M.;Yap, Alpha S.
经典的钙粘附素黏附受体通过与细胞骨架的密切合作发挥许多生物学效应。很多注意力集中在试图了解钙粘蛋白分子复合体和皮质肌动蛋白细丝之间的物理相互作用。在这篇综述中，我们旨在引起人们对其他问题的关注，这些问题突出了与钙粘附素功能有关的各种动态细胞骨架。首先，我们讨论了基于钙粘附素的连接细胞骨架中肌动蛋白细丝的动态调节，重点讨论了Arp2/3作为连接肌动蛋白核因子的新角色及其对连接处肌动蛋白动态平衡的影响。其次，我们回顾了微管对钙粘附素功能影响的最新研究进展。总之，这些都强调了钙粘附素在细胞-细胞连接处与多个动态的细胞骨架网络合作。
Classical cadherin adhesion receptors exert many of their biological effects through close cooperation with the cytoskeleton. Much attention has focused on attempting to understand the physical interactions between cadherin molecular complexes and cortical actin filaments. In this review we aim to draw attention to other issues that highlight the diverse and dynamic cytoskeletons that contribute to cadherin function. First, we discuss the regulation of actin filament dynamics in the cadherin-based junctional cytoskeleton, focusing on the emerging role of Arp2/3 as a junctional actin nucleator and its implications for actin homeostasis at junctions. Second, we review recent developments in understanding the impact of microtubules on cadherin function. Together, these emphasize that cadherins cooperate with multiple dynamic cytoskeletal networks at cell-cell junctions.