Eye tracking indices of attentional bias in children of depressed mothers: Polygenic influences help to clarify previous mixed findings.
Eye tracking indices of attentional bias in children of depressed mothers: Polygenic influences help to clarify previous mixed findings.
复制标题
抑郁母亲的孩子注意力偏差的眼动追踪指数：多基因影响有助于澄清以前的混合发现。
DOI：
10.1017/s0954579415000462
复制
发表时间：
2016
影响因子：
3.3
通讯作者：
Gibb,BrandonE
中科院分区：
文献类型：
--
作者：
Owens,Max;Harrison,AshleyJ;Burkhouse,KatieL;McGeary,JohnE;Knopik,ValerieS;Palmer,RohanHC;Gibb,BrandonE
信息处理偏差可能会导致抑郁症的代际传播。越来越多的证据表明，抑郁母亲的孩子会对悲伤的面孔表现出注意力偏差。然而，关于这种偏见是否反映了对悲伤面孔的优先关注，而不是对悲伤面孔的注意力回避，研究结果不一，这表明存在未衡量的调节者。为了解决这些复杂的发现，我们关注与下丘脑-垂体-肾上腺轴反应性相关的基因的潜在调节作用。参与者包括母亲有抑郁症病史（n = 81）和没有抑郁症病史（n = 81）的孩子（8-14 岁）。当孩子们被动地观看一系列愤怒、快乐、悲伤和中性的面孔时，眼球运动被记录下来。 DNA 是从口腔细胞中获得的。与非抑郁母亲的孩子相比，抑郁母亲的孩子对悲伤的面孔表现出更持续的关注。然而，重要的是这种关系受到儿童基因型的调节。具体来说，如果抑郁症母亲的孩子在促肾上腺皮质激素释放激素 1 型受体 (CHRH1) TAT 单倍型和 FK506 结合蛋白 5 (FKBP5) rs1360780（但不是血清素转运蛋白连接多态性区域 [5-HTTLPR] 的溶质载体家族 C6 成员 4 [SLC6A4]）上携带反应性基因型，则对悲伤面孔的持续关注较少，而对悲伤面孔的持续关注则更持久。注意幸福的面孔。这些发现强调了特定遗传影响所发挥的作用，并表明先前的混合发现可能是由于样本之间的遗传异质性造成的。
Information-processing biases may contribute to the intergenerational transmission of depression. There is growing evidence that children of depressed mothers exhibit attentional biases for sad faces. However, findings are mixed as to whether this bias reflects preferential attention toward, versus attentional avoidance of, sad faces, suggesting the presence of unmeasured moderators. To address these mixed findings, we focused on the potential moderating role of genes associated with hypothalamic–pituitary–adrenal axis reactivity. Participants included children (8–14 years old) of mothers with (n = 81) and without (n = 81) a history of depression. Eye movements were recorded while children passively viewed arrays of angry, happy, sad, and neutral faces. DNA was obtained from buccal cells. Children of depressed mothers exhibited more sustained attention to sad faces than did children of nondepressed mothers. However, it is important that this relation was moderated by children's genotype. Specifically, children of depressed mothers who carried reactive genotypes across the corticotropin-releasing hormone type 1 receptor (CHRH1) TAT haplotype and FK506 binding protein 5 (FKBP5) rs1360780 (but not the solute carrier family C6 member 4 [SLC6A4] of the serotonin transporter linked polymorphic region [5-HTTLPR]) exhibited less sustained attention to sad faces and more sustained attention to happy faces. These findings highlight the role played by specific genetic influences and suggest that previous mixed findings may have been due to genetic heterogeneity across the samples.