The 6-Minute Walk Test and Person-Reported Outcomes in Boys with Duchenne Muscular Dystrophy and Typically Developing Controls: Longitudinal Comparisons and Clinically-Meaningful Changes Over One Year.
The 6-Minute Walk Test and Person-Reported Outcomes in Boys with Duchenne Muscular Dystrophy and Typically Developing Controls: Longitudinal Comparisons and Clinically-Meaningful Changes Over One Year.
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DOI：
10.1371/currents.md.9e17658b007eb79fcd6f723089f79e06
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发表时间：
2013-07-08
期刊：
影响因子：
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通讯作者：
McDonald, Craig M
中科院分区：
文献类型：
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作者：
Henricson, Erik;Abresch, Richard;McDonald, Craig M
简介：数据目前缺乏锚定的30米纵向变化的步行能力6分钟步行试验（6 MWT）在杜氏肌营养不良症作为一个最小的临床重要的差异和“临床有意义的”个人报告的结果（PRO）在不同水平的走动能力。我们描述了测量之间的相关性，测量的1年变化，以及6分钟步行试验（6 MWT）测量之间1年变化的相关性，10米跑/步行速度，PedsQL和POSNA儿科结局数据收集工具（PODCI）在24名4-12岁的儿童中进行。结果：PedsQL总功能、躯体功能、PODCI总体功能、转移/移动功能和运动/躯体功能PRO在DMD组和对照组之间有显著性差异（P < 0.05），而在正常对照组和对照组之间无显著性差异（P > 0.05）。
INTRODUCTION: Data is currently lacking anchoring a 30-meter longitudinal change in walking ability by 6-minute walk test (6MWT) in Duchenne muscular dystrophy as a minimal clinically important difference and "clinically meaningful" person-reported outcomes (PROs) at differing levels of ambulatory ability.METHODS: We describe correlation between measures, 1-year change in measures, and correlation of 1-year changes between measures for the six-minute walk test (6MWT), 10-meter run/walk velocity, PedsQL and POSNA Pediatric Outcomes Data Collection Instrument (PODCI) in 24 4-12 year old. ambulatory DMD and 36 typical controls, and determine if minimal clinically important differences (MCID) of PROs contribute to different estimates of 6-minute walk distance (6MWD) change at differing levels of ability.RESULTS: PedsQL total and physical function and PODCI global, transfer/mobility and sports/physical function PROs demonstrated significant differences between DMD and controls (p