A role for correlated spontaneous activity in the assembly of neural circuits.
A role for correlated spontaneous activity in the assembly of neural circuits.
复制标题
相关的自发活动在神经回路组装中的作用。
DOI：
10.1016/j.neuron.2013.10.030
复制
发表时间：
2013-12-04
期刊：
影响因子：
16.2
通讯作者：
Feller MB
中科院分区：
文献类型：
--
作者：
Kirkby LA;Sack GS;Firl A;Feller MB
在感觉传导开始之前，发育中的神经回路自发地产生不同空间和时间模式的相关活动。在这段有模式的活动期间，感觉图谱的形成和最初的粗略连接被提炼，这是建立成人神经回路的关键步骤。在过去的十年里，有大量证据表明，改变自发活动的模式会破坏精致，但对这一过程的机械性理解仍然不完整。在这篇综述中，我们讨论了最新的实验和理论进展，以活动依赖的精炼过程，重点是在视觉，听觉和运动系统的电路。虽然仍有许多悬而未决的问题，但几种新方法的结合让我们更接近于全面理解复杂的神经回路是如何通过发育过程中模式化的自发活动建立起来的。
Before the onset of sensory transduction, developing neural circuits spontaneously generate correlated activity in distinct spatial and temporal patterns. During this period of patterned activity, sensory maps develop and initial coarse connections are refined, which are critical steps in the establishment of adult neural circuits. Over the last decade there has been substantial evidence that altering the pattern of spontaneous activity disrupts refinement, but the mechanistic understanding of this process remains incomplete. In this review, we discuss recent experimental and theoretical progress towards the process of activity-dependent refinement, focusing on circuits in the visual, auditory and motor systems. While many outstanding questions remain, the combination of several novel approaches have brought us closer to a comprehensive understanding of how complex neural circuits are established by patterned spontaneous activity during development.