Alexithymia and apathy in Parkinson's disease: neurocognitive correlates.
Alexithymia and apathy in Parkinson's disease: neurocognitive correlates.
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DOI：
10.3233/ben-129021
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发表时间：
2013-01-01
影响因子：
2.8
通讯作者：
Cronin-Golomb A
中科院分区：
文献类型：
--
作者：
Bogdanova Y;Cronin-Golomb A
非运动症状，如神经精神和认知功能障碍已被发现是常见的帕金森病（PD），但这些症状之间的关系知之甚少。我们专注于述情障碍，一种情感和认知情绪处理的障碍，因为有证据表明它与其他疾病的认知相互作用。22名非痴呆PD患者和22名匹配的正常对照成年人（NC）进行评定量表评估神经精神状态，包括述情障碍，冷漠和抑郁，和一系列的神经心理学测试。正如预期的那样，PD患者比NC患者表现出更多的述情障碍，并且述情障碍与疾病分期之间存在显著相关性。述情障碍与执行和视觉空间功能的非言语介导的措施，但不口头介导的任务的性能。相比之下，认知与抑郁或冷漠的评级之间没有相关性。我们的研究结果表明，述情障碍与非言语认知在PD，涉及右半球的过程，并区分述情障碍和其他神经精神症状方面的PD认知的一个独特的关联。
Non-motor symptoms such as neuropsychiatric and cognitive dysfunction have been found to be common in Parkinson’s disease (PD) but the relation between such symptoms is poorly understood. We focused on alexithymia, an impairment of affective and cognitive emotional processing, as there is evidence for its interaction with cognition in other disorders. Twenty-two non-demented PD patients and 22 matched normal control adults (NC) were administered rating scales assessing neuropsychiatric status, including alexithymia, apathy, and depression, and a series of neuropsychological tests. As expected, PD patients showed more alexithymia than NC, and there was a significant association between alexithymia and disease stage. Alexithymia was associated with performance on non-verbally mediated measures of executive and visuospatial function, but not on verbally mediated tasks. By contrast, there was no correlation between cognition and ratings of either depression or apathy. Our findings demonstrate a distinct association of alexithymia with non-verbal cognition in PD, implicating right hemisphere processes, and differentiate between alexithymia and other neuropsychiatric symptoms in regard to PD cognition.